ERJOR Early View

September 12, 2024

Original Research Article
A strong association between TTF-1 expression and ILD in predicting the efficacy of PD-1 inhibitor for non-squamous NSCLC patients
Masaru Ito, Takayuki Honda, Iichiroh Onishi, Satoshi Endo, Akifumi Mochizuki, Naoki Nishiyama, Rie Sakakibara, Susumu Takahashi, Takashi Kumagai, Koki Hata, Sao Yoshii, Kentaro Nakamura, Takaaki Yamashita, Yoshikazu Tsukada, Tomoshige Chiaki, Yoshihiro Miyashita, Ichirou Natsume, Kazuhito Saitou, Yasunari Miyazaki

ERJ Open Research; DOI: 10.1183/23120541.00628-2024
Original Research Article
Acute exacerbations in patients with progressive pulmonary fibrosis
Michael Kreuter, Elizabeth A Belloli, Elisabeth Bendstrup, Stefania Cerri, Kevin R Flaherty, Shane Shapera, Jin Woo Song, Heiko Mueller, Klaus B Rohr, Yasuhiro Kondoh on behalf of the INBUILD trial investigators

ERJ Open Research; DOI: 10.1183/23120541.00403-2024
Original Research Article
Remote monitoring of patients with chronic obstructive pulmonary disease using a tablet system: a randomised cross over study of quality of life measurements
Malte Frerichs, Huiqi Li, Anders Andersson, Kristina Andelid, Monica Crona, Lowie E.G.W. Vanfleteren

ERJ Open Research; DOI: 10.1183/23120541.00532-2024

August 30, 2024

Original Research Article
IL1RL1 variant may affect the response to type 2 biologics in patients with severe asthma
Kenta Nishi, Hisako Matsumoto, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Noriyuki Tashima, Yusuke Hayashi, Satoru Terada, Kyohei Morita, Chie Yoshimura, Yasuo Nishizaka, Akiko Sano, Takashi Iwanaga, Hiroyuki Sano, Ryuta Haraguchi, Yuji Tohda, Takahisa Kawaguchi, Fumihiko Matsuda, Toyohiro Hirai

ERJ Open Research; DOI: 10.1183/23120541.00448-2024
Original Research Article
Sleep Apnoea, Cognition and Aspirin's effects in healthy older people: an ASPREE sub-study
Stephanie A Ward, Robyn L Woods, Matthew T Naughton, Rory Wolfe, Danijela Gasevic, Garun S Hamilton, Walter p Abhayaratna, Katherine Webb, Fergal J O'Donoghue, Nigel Stocks, Ruth E Trevaks, Sharyn M Fitzgerald, Suzanne G Orchard, Christopher M Reid, Elsdon Storey

ERJ Open Research; DOI: 10.1183/23120541.00581-2024

August 22, 2024

Original Research Article
Brensocatib in Patients With Bronchiectasis: Subgroup Analyses From the WILLOW Trial
James D. Chalmers, Michael R. Loebinger, Ariel Teper, Pamela J. McShane, Carlos Fernandez, Sebastian Fucile, Charles S. Haworth, Melanie Lauterio, Roald van der Laan, Vivian H. Shih, Mark L. Metersky

ERJ Open Research; DOI: 10.1183/23120541.00505-2024
Study Protocol
The Canadian Bronchiectasis and Nontuberculous Mycobacteria Registry: A Study Protocol
Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, Sarah Brode, Theodore K. Marras, Ryan Cooper, Maeve Smith, Julie Jarand

ERJ Open Research; DOI: 10.1183/23120541.00412-2024
Research Letter
The carbon footprint of diagnostic delays in asthma
Lauranne Pouliot, Laurence Désy, Sarah-Ève Lemieux, Carlos Andrés Celis-Preciado, Samuel Lemaire-Paquette, Martine Duval, Simon Leclerc, Félix-Antoine Vézina, Philippe Lachapelle, Simon Couillard

ERJ Open Research; DOI: 10.1183/23120541.00577-2024
Original Research Article
Effects of nintedanib on circulating biomarkers of idiopathic pulmonary fibrosis
R Gisli Jenkins, Vincent Cottin, Yasuhiko Nishioka, Imre Noth, Eric S White, Carina Ittrich, Claudia Diefenbach, Klaus B Rohr, Moisés Selman, Toby M Maher on behalf of the INMARK trial investigators

ERJ Open Research; DOI: 10.1183/23120541.00558-2023
Original Research Article
Inhaled alpha-1-antitrypsin (AAT) restores lower respiratory tract protease- anti-protease homeostasis and reduces inflammation in AAT-deficient individuals: A randomised phase 2 study
Mark Brantly, James Stocks, Jorge Lascano, Tammy Flagg, Ann M. Jeffers, Shuzi Z. Owens, Torry A. Tucker, Megan Devine, Noga Alagem, Naveh Tov

ERJ Open Research; DOI: 10.1183/23120541.00537-2024
Original Research Article
Achieving Adherence to Positive Airway Pressure in Commercial Drivers using an Employer-mandated Remote Management Program
Elizabeth Kneeland, Nadia Ali, David G. Maislin, Yoon Hee Chang, Joyce Epelboim, Brendan T. Keenan, Allan I. Pack

ERJ Open Research; DOI: 10.1183/23120541.00132-2024
Original Research Article
Automated method of bronchus and artery dimensions of an adult bronchiectasis population
Angelina L.P. Pieters, Qianting Lv, Jennifer J. Meerburg, Tjeerd van der Veer, Eleni-Rosalina Andrinopoulou, Pierluigi Ciet, James D Chalmers, Michael R. Loebinger, Charles S. Haworth, Joseph Stuart Elborn, Harm A.W.M. Tiddens, on behalf of the iABC study group

ERJ Open Research; DOI: 10.1183/23120541.00231-2024
Original Research Article
Surfactant derived protein type B: a new biomarker linked to respiratory failure and lung damage in mild to moderate SARS-CoV-2 pneumonia
Massimo Mapelli, Elisabetta Salvioni, Irene Mattavelli, Cristina Banfi, Stefania Ghilardi, Arianna Greco, Maria Luisa Biondi, Sara Rovai, Elisabetta Mancini, Sergio Harari, Piergiuseppe Agostoni

ERJ Open Research; DOI: 10.1183/23120541.00301-2024
Research Letter
Chronobiology in breathlessness across 24 hours in people with persistent breathlessness
Jacob Sandberg, Josefin Sundh, Peter Anderberg, Miriam J Johnson, David C Currow, Magnus Ekström

ERJ Open Research; DOI: 10.1183/23120541.00417-2024
Research Letter
Change in self-efficacy mediates the effect of a physical activity intervention in COPD
Stephanie A. Robinson, Patricia M. Bamonti, Emily S. Wan, Marilyn L. Moy

ERJ Open Research; DOI: 10.1183/23120541.00713-2024
Original Research Article
The effect of triple CFTR modulator therapy and azithromycin on ion channels and inflammation in cystic fibrosis
Suhad Bani Melhim, Lisa E.J. Douglas, James A. Reihill, Damian G. Downey, S. Lorraine Martin

ERJ Open Research; DOI: 10.1183/23120541.00502-2024
Original Research Article
Chronic Cough Patient Perspective: questionnaire validation and symptom impact
Fulvio Braido, Maria Giulia Candeliere, Benedetta Bondi, Enrico Arnaboldi, Matteo Bruno, Nicole Colombo, Cesare de Tommaso, Omar Fassio, Melissa Ferraris, Sofia Martinelli, Laura Melissari, Ludovica Napoli, Federica Terracciano, Chiara Folli, Ilaria Baiardini

ERJ Open Research; DOI: 10.1183/23120541.00221-2024
Original Research Article
DElaying disease Progression In COPD with early escalation to Triple therapy – A Modelling Study (DEPICT-2)
Dave Singh, Diego Fabian Litewka, Joan B Soriano, Adrian Rendon, Frederico Leon Arrabal Fernandes, Rafael Páramo-Arroyo, Tim Trinidad, Hakan Günen, Sudeep Acharya, Bhumika Aggarwal, Gur Levy, Chris Compton, Abdelkader El Hasnaoui, Peter Daley-Yates

ERJ Open Research; DOI: 10.1183/23120541.00438-2024
Original Research Article
Serum metalloproteinase-7 as a biomarker of progressive pulmonary fibrosis
Márcia Araújo, Marília Beltrão, Oksana Sokhatska, Natália Melo, Patrícia Caetano Mota, Helder Novais Bastos, André Terras, David Coelho, Luís Delgado, António Morais

ERJ Open Research; DOI: 10.1183/23120541.00553-2024
Original Research Article
Utility of adding esophageal to endobronchial endosonography when staging lung cancer: A randomized trial
Masahide Oki, Hideo Saka, Yukio Seki, Yoshihito Kogure, Hideyuki Niwa, Arisa Yamada, Atsushi Torii, Chiyoe Kitagawa, Masahiko Ando

ERJ Open Research; DOI: 10.1183/23120541.00326-2024
Original Research Article
Childhood lung function is associated with adolescent-onset and persistent asthma
Hans Jacob L. Koefoed, Anhar Ullah, Jenny Hallberg, Simon Kebede Merid, Maura M. Kere, Lesley Lowe, Angela Simpson, Clare S. Murray, Ulrike Gehring, Roel Vermeulen, Inger Kull, Anna Bergström, Judith M. Vonk, Adnan Custovic, Erik Melén, Gerard H. Koppelman

ERJ Open Research; DOI: 10.1183/23120541.00469-2024
Original Research Article
Variability in Disease Severity Among Cystic Fibrosis Patients carrying Residual Function Variants: Data from the European Cystic Fibrosis Society Patient Registry
Meir Mei-Zahav, Annalisa Orenti, Andreas Jung, Eitan Kerem ECFSPR Steering Group

ERJ Open Research; DOI: 10.1183/23120541.00587-2024
Original Research Article
Definition of sinonasal and otologic exacerbation in patients with primary ciliary dyskinesia - an expert consensus
Myrofora Goutaki, Yin Ting Lam, Andreas Anagiotos, Miguel Armengot, Andrea Burgess, Raewyn Campbell, Mathilde Carlier, Nathalie Caversaccio, Neil K. Chadha, Berat Demir, Sinan Ahmed D. Dheyauldeen, Onder Gunaydin, Amanda Harris, Isolde Hayn, Deniz Inal-Ince, Eric Levi, Trini Lopez Fernandez, Jane S. Lucas, Bernard Maitre, Anne-Lise ML Poirrier, Lynne Schofield, Kazuhiko Takeuchi, Christine van Gogh, Nikolaus E. Wolter, Jean-François Papon

ERJ Open Research; DOI: 10.1183/23120541.00218-2024
Original Research Article
Control of hypercapnia and mortality in home mechanical ventilation – the population-based DISCOVERY study
Andreas Palm, Magnus Ekström, Össur Emilsson, Karin Ersson, Mirjam Ljunggren, Josefin Sundh, Ludger Grote

ERJ Open Research; DOI: 10.1183/23120541.00461-2024
Original Research Article
High frequency percussive ventilation in acute respiratory failure
Andrea Bruni, Giuseppe Neri, Gianmaria Cammarota, Vincenzo Bosco, Eugenio Biamonte, Letizia Troisi, Annalisa Boscolo, Paolo Navalesi, Federico Longhini, Eugenio Garofalo

ERJ Open Research; DOI: 10.1183/23120541.00401-2024
Original Research Article
Physiological effects of high-flow nasal cannula during sustained high-intensity exercise in healthy volunteers: a randomised crossover trial
Eduardo Moya-Gallardo, Patricio Garcia-Valdés, Consuelo Marambio-Coloma, Constanza Gutierrez-Escobar, Betsabeth Hernández-Vargas, Carolina Muñoz-Castro, Santiago Riquelme-Sánchez, Joel Moo-Millán, Roque Basoalto, Alejandro Bruhn, Orlando Diaz, L. Felipe Damiani

ERJ Open Research; DOI: 10.1183/23120541.00482-2024

August 08, 2024

Original Research Article
Supplementary Oxygen Efficacy for Chronic Pulmonary Disorders and Exertion Desaturation
Paraschos Archontakis Barakakis, Adam Wolfe, Andrei Schwartz, Gabriel J. Hernandez Romero, Vipul Gidwani, Shaylika Chauhan, Shinichi Arizono, Ralph J. Panos, Spyridon Fortis

ERJ Open Research; DOI: 10.1183/23120541.00411-2024
Original Research Article
Impact of ultrasound settings on lung vertical artifacts: an observational study in mechanically ventilated patients
Joao Leote, Andreia Gonçalves, Júlia Fonseca, Ricardo Loução, Hermínia Dias, Maria Inês Ribeiro, Ricardo Meireles, Rita Varudo, Jacobo Bacariza, Filipe Gonzalez on behalf of EchoCrit group

ERJ Open Research; DOI: 10.1183/23120541.00483-2024
Original Research Article
Time is lung: Higher preservation of lung function in severe asthma patients after earlier mepolizumab treatment
Francisco-Javier González-Barcala, Irina Bobolea, Javier Domínguez-Ortega, David Bañas-Conejero, Esteban Antelo-Cea, Eva Martínez-Moragón, Teresa Carrillo, Marina Blanco-Aparicio, Christian Domingo

ERJ Open Research; DOI: 10.1183/23120541.00211-2024
Original Research Article
Oscillometry Reference Values for Children and Adolescents
Christoph Valach, Emiel F. M. Wouters, Alina Ofenheimer, Pasquale Pio Pompilio, Alessandro Gobbi, Marie-Kathrin Breyer, Sylvia Hartl, Chiara Veneroni, Tobias Mraz, Caspar Schiffers, Otto Chris Burghuber, Ahmad Karimi, Christoph Gross, Charles Irvin, Robab Breyer-Kohansal

ERJ Open Research; DOI: 10.1183/23120541.00278-2024
Original Research Article
Dry Powder Inhaler Use in Primary School Aged Children with Asthma: A Systematic Review
Stephanie L Kuek, Nicole X Wong, Stuart Dalziel, Lee Hatter, Louise Fleming, Andrew Bush, Richard Beasley, Shivanthan Shanthikumar

ERJ Open Research; DOI: 10.1183/23120541.00455-2024
Original Research Article
Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension
Anna Kirillova, Meena Sethuraman, Xishuang Dong, Almina Kirdar, Gil Speyer, Yassmin Al Aaraj, Annie Watson, Lily K. Schneider, Michael D. Creager, Robert Lafyatis, Satoshi Okawa, Seungchan Kim, Stephen Y. Chan

ERJ Open Research; DOI: 10.1183/23120541.00486-2024
Original Research Article
Evaluation of e-Lung automated quantitative CT biomarkers in idiopathic pulmonary fibrosis
Peter M George, Christian Rennison-Jones, Giacomo Benvenuti, Aliki Sifostratoudaki, Finja Ottink, Wassim Bou-Zeid, Roberta Eufrasia Ledda, Roqia Fatmawati, Abul Kadir, Bushra Johari, Claire Fernandez, George Harston, Olivier Joly, Stephen Gerry, Anand Devaraj

ERJ Open Research; DOI: 10.1183/23120541.00570-2024
Original Research Article
Validation of new predictors of mortality and BODE index variants in patients with COPD at moderate altitude
Robinson Robles-Hernández, Gustavo I. Centeno-Saenz, Alejandra Ramírez-Venegas, Ireri Thirion-Romero, Rafael Hernández-Zenteno, Sandra P. Guinto-Ramírez, María C. Maya-García, Diana Villegas-Trejo, Francisco Montiel-López, Lila M. Cordero-Silis, Rogelio Pérez-Padilla

ERJ Open Research; DOI: 10.1183/23120541.00333-2024
Study Protocol
The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol
Christine M. Liu, Jakob L. Fischer, Edith T. Zemanick, Jason C. Woods, Karolin K. Markarian, Sean B. Fain, Deborah Froh, Sonya L. Heltshe, Lucas R. Hoffman, Stephen M. Humphries, Elizabeth L. Kramer, Katie Larson Ode, Michael Lewis, Douglas A. Li, Jaime Mata, Sarah S. Milla, Peter J. Niedbalski, Benjamin D. Sawatzky, Myung-Shin Sim, Jillian S. Sullivan, Andrew T. Trout, Christopher H. Goss, Jennifer L. Taylor-Cousar, Daniel M. Beswick

ERJ Open Research; DOI: 10.1183/23120541.00137-2024

August 01, 2024

Original Research Article
Anti-IL-5/anti-IL-5Rα treatment improves self-reported work productivity in patients with severe eosinophilic asthma – a prospective cohort trial
Lina Brinkmann, Jan Fuge, Tobias Welte, Hendrik Suhling, Nora Drick

ERJ Open Research; DOI: 10.1183/23120541.00374-2024
Original Research Article
Therapeutic Doses of Efzofitimod Demonstrate Efficacy in Pulmonary Sarcoidosis
Ogugua Ndili Obi, Robert P. Baughman, Elliott D. Crouser, Mark W. Julian, Landon W. Locke, Abhijeeth Chandrasekaran, Pavithra Ramesh, Nelson Kinnersley, Vis Niranjan, Daniel A. Culver, Peter H. S. Sporn

ERJ Open Research; DOI: 10.1183/23120541.00536-2024
Original Research Article
Impact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort
Rosa A. Sola-Martínez, Pedro Jiménez-Guerrero, Manuel Sánchez-Solís, Gema Lozano-Terol, Julia Gallego-Jara, Adrián Martínez-Vivancos, Eva Morales, Luis García-Marcos, Teresa de Diego Puente, on behalf of the NELA Study Group

ERJ Open Research; DOI: 10.1183/23120541.00597-2024
Research Letter
Incidence of acute exacerbations of chronic respiratory disease during pulmonary rehabilitation delivered at home or hospital
Angela T Burge, Narelle S Cox, Arkash Ponnudurai, Anne E Holland, Janet Bondarenko, Catherine J Hill, Arwel W Jones

ERJ Open Research; DOI: 10.1183/23120541.00209-2024
Original Research Article
Association between impaired diffusion capacity and small airway dysfunction: a cross-sectional study
Kunning Zhou, Fan Wu, Lifei Lu, Gaoying Tang, Zhishan Deng, Cuiqiong Dai, Ningning Zhao, Qi Wan, Jieqi Peng, Xiaohui Wu, Xianliang Zeng, Jiangyu Cui, Changli Yang, Shengtang Chen, Yongqing Huang, Shuqing Yu, Yumin Zhou, Pixin Ran on behalf of the ECOPD study investigators

ERJ Open Research; DOI: 10.1183/23120541.00910-2023
Original Research Article
Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma
Amir Hossein Alizadeh Bahmani, Susanne J.H. Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M. Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D. Kraneveld, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S Dierdorp, Tamara Dekker, Nariman K. A. Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I. Abdel-Aziz, Anke H. Maitland-van der Zee on behalf of the SysPharmPediA consortium

ERJ Open Research; DOI: 10.1183/23120541.00222-2024
Original Research Article
Biomarkers Troponin and Procalcitonin in Addition to CRB-65 Enhance Risk Stratification in Patients with CAP
Imrana Farhat, Maciej Rosolowski, Katharina Ahrens, Jasmin Lienau, Peter Ahnert, Mathias Pletz, Gernot Rohde, Jan Rupp, CAPNETZ Study Group, Markus Scholz, Martin Witzenrath

ERJ Open Research; DOI: 10.1183/23120541.00420-2024
Research Letter
Falling through the cracks: what happens to survivors of preterm birth?
Andrew Bush, Anne Greenough, Alvar Agustí, Federico Bianco, Eugenio Baraldi, on behalf of the PRE-TELL Group

ERJ Open Research; DOI: 10.1183/23120541.00643-2024
Original Research Article
Activity behaviours and quality of life in patients with malignant pleural effusion
Bianca M. Iacopetta, David C.L. Lam, Jenny C.L. Ngai, Johnny W.M. Chan, Fifian K.Y Chiang, Macy M.S. Lui, W.L. Law, Ken K.P. Chan, Joanne Mcveigh, Carolyn J. McIntyre, Y.C Gary Lee

ERJ Open Research; DOI: 10.1183/23120541.00399-2024

July 18, 2024

Original Research Article
The prevalence and implications of depression and anxiety in patients with bronchiectasis: a systematic review and meta-analysis
Min-Seok Chang, Hyun-Jung Kim, Ji-Ho Lee

ERJ Open Research; DOI: 10.1183/23120541.00248-2024
Original Research Article
Pulmonary fibrosis in patients with auto-immune pulmonary alveolar proteinosis: a retrospective nationwide cohort study
Yoann Guirriec, David Luque-Paz, Gontran Bernard, Axelle Mabo, Mallorie Kerjouan, Cédric Ménard, Delphine Monnier, Hilario Nunes, Yurdagül Uzunhan, Martine Reynaud-Gaubert, Julien Bermudez, Raphaël Borie, Bruno Crestani, Julie Traclet, Lidwine Wémeau-Stervinou, Cécile Chenivesse, Emmanuel Gomez, Grégoire Prévot, Arnaud Bourdin, Benjamin Bondue, Anne Bergeron, Vincent Cottin, Mathieu Lederlin, Stéphane Jouneau, OrphaLung network

ERJ Open Research; DOI: 10.1183/23120541.00314-2024
Original Research Article
Neutrophil extracellular traps are associated with airways inflammation and increased severity of lung disease in Cystic Fibrosis
Sheonagh M Law, Gareth Hardisty, Jonathan L Gillan, Nicola J Robinson, Donald J Davidson, Moira KB Whyte, Ian Dransfield, Robert D Gray

ERJ Open Research; DOI: 10.1183/23120541.00312-2024
Research Letter
Long-term dupilumab efficacy in type 2 asthma regardless of baseline characteristics
Michael E. Wechsler, Linda Rogers, G. Walter Canonica, Arnaud Bourdin, Arman Altincatal, Megan Hardin, Xavier Soler, Paul J. Rowe, Yamo Deniz, Harry Sacks, Juby A. Jacob-Nara

ERJ Open Research; DOI: 10.1183/23120541.00188-2024

July 11, 2024

Research Letter
Matrix metalloprotease-7 is associated with post-COVID persistent lung abnormalities.
Ivette Buendia-Roldan, Leslie Chavez-Galan, Hiram Aguilar-Duran, Andy Ruiz, Ramcés Falfan-Valencia, Gloria Pérez-Rubio, Annie Pardo, Moisés Selman

ERJ Open Research; DOI: 10.1183/23120541.00266-2024
Original Research Article
Abnormal breathing pattern features in chronic refractory cough
Jordan Jeffery, Anne E Vertigan, Sarah Bone, Peter G Gibson

ERJ Open Research; DOI: 10.1183/23120541.00416-2024

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