Comparison of genome-wide gene expression profiling by RNA-Seq versus microarray in bronchial biopsies of COPD patients before and after ICS treatment. Does it provide new insights?
- Benedikt Ditz1,2,10,
- Jeunard G. Boekhoudt2,3,10,
- Hananeh Aliee4,
- Fabian J. Theis4,5,
- Martijn Nawijn2,3,
- Corry-A Brandsma2,3,
- Pieter S. Hiemstra6,
- Wim Timens2,3,
- Gaik W. Tew7,
- Michele A. Grimbaldeston7,
- Margaret Neighbors7,
- Victor Guryev8,
- Maarten van den Berge1,2,11 and
- Alen Faiz1,2,9,11
- 1Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 2University of Groningen, University Medical Center Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), Groningen, The Netherlands
- 3Department of Pathology & Medical Biology, section Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 4Institute of Computational Biology, Helmholtz Centre, Munich, Germany
- 5Department of Mathematics, Technical University of Munich, Munich, Germany
- 6Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
- 7OMNI Biomarker Development, Genentech Inc, South San Francisco, USA
- 8European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
- 9Faculty of Science, University of Technology Sydney, Ultimo, NSW, Australia
- 10shared first author
- 11shared last author
- Alen Faiz, Respiratory Bioinformatics and Molecular Biology (RBMB), School of Life Sciences, University of Technology Sydney, Sydney, Australia. E-mail: a.faiz{at}umcg.nl
Footnotes
This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Ditz has nothing to disclose.
Conflict of interest: Jeunard Boekhoudt has nothing to disclose.
Conflict of interest: Dr. Aliee has nothing to disclose.
Conflict of interest: Dr. Theis has nothing to disclose.
Conflict of interest: Dr. Nawijn reports grants from European Commission (EU H2020 program), grants from GSK Ltd, grants from Lung Foundation Netherlands, during the conduct of the study.
Conflict of interest: Dr. Brandsma has nothing to disclose.
Conflict of interest: Dr. Hiemstra has nothing to disclose.
Conflict of interest: Dr. Timens reports personal fees from Roche Diagnostics / Ventana, personal fees from Merck Sharp Dohme, personal fees from Bristol-Myers-Squibb, personal fees from Diaceutics, outside the submitted work.
Conflict of interest: Dr. Tew reports and Gaik W. Tew is an employee of Genentech Inc., a Member of the Roche Group.
Conflict of interest: Dr. Grimbaldeston reports she is an employee of Genentech Inc., a Member of the Roche Group.
Conflict of interest: Dr. Neighbors reports I am a full time employee of Genentech, Inc and hold stock and options in the Roche Group.
Conflict of interest: Dr. Guryev has nothing to disclose.
Conflict of interest: Dr. Van Den Berge has nothing to disclose.
Conflict of interest: Dr. Faiz has nothing to disclose.
This is a PDF-only article. Please click on the PDF link above to read it.
- Received February 11, 2021.
- Accepted March 2, 2021.
- Copyright ©The authors 2021
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