“Changes in health-related quality of life as a marker in the prognosis in COPD patients”
- Cristóbal Esteban1,3,5⇑,
- Inmaculada Arostegui2,
- Amaia Aramburu1,5,
- Javier Moraza1,5,
- Myriam Aburto1,5,
- Susana Aizpiri1,5,
- Leyre Chasco1,5 and
- José M. Quintana3,4,6
- 1Respiratory Department, Hospital Galdakao, Galdakao, Bizkaia, Spain
- 2Department of Applied Mathematics, Statistics and Operative Research, University of the Basque Country (UPV/EHU) and Basque Center for Applied Mathematics (BCAM), Spain
- 3Research Unit, Hospital Galdakao, Galdakao, Bizkaia, Spain
- 4Health Services Research on Chronic Patients Network (REDISSEC)
- 5BioCruces-Bizkaia Health Research Institute, Baracaldo, Spain
- 6Kronikgune Research Institute, Baracaldo, Spain
- CRISTÓBAL ESTEBAN (cristobal.est{at}gmail.com)
Abstract
Chronic obstructive pulmonary disease (COPD) is understood as a complex, heterogeneous and multisystem airway obstructive disease. The association of deterioration in health-related quality of life (HRQoL) with mortality and hospitalisation for COPD exacerbation has been explored in general terms. The specific objectives of this study were to determine whether a change in HRQoL is related over time with mortality and hospitalisation. Overall, 543 patients were recruited through Galdakao Hospital's five outpatient respiratory clinics. Patients were assessed at baseline and the end of the first and second year and were followed-up for 3 years. At each assessment, measurements were made of several variables, including HRQoL using the Saint George's Respiratory Questionnaire (SGRQ). The cohort had moderate obstruction (FEV1 55% of the predicted value). SGRQ total, symptoms, activity and impact scores at baseline were 39.2, 44.5, 48.7 and 32.0, respectively. Every 4-point increase in the SGRQ was associated with an increase in the likelihood of death: “symptoms” domain odds ratio (OR)=1.04; 95% CI (1.00–1.08); “activity” domain OR=1.12; 95% CI (1.08–1.17) and “impacts” domain OR=1.11; 95% CI (1.06–1.15). The rate of hospitalisations per year was 5% (95% CI 3%-8%) to 7% (95% CI 5%-10%) higher for each 4-point increase in the separate domains of the SGRQ. Deterioration in HRQoL by 4 points in SGRQ domain scores over 1 year was associated with an increased likelihood of death and hospitalisation.
Footnotes
This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Esteban has nothing to disclose.
Conflict of interest: Dr. Arostegui has nothing to disclose.
Conflict of interest: Dr. Aramburu has nothing to disclose.
Conflict of interest: Dr. Moraza has nothing to disclose.
Conflict of interest: Dr. Aburto has nothing to disclose.
Conflict of interest: Dr. Aizpiri has nothing to disclose.
Conflict of interest: Dr. Chasco has nothing to disclose.
Conflict of interest: Dr. Quintana has nothing to disclose.
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- Received March 14, 2021.
- Accepted October 13, 2021.
- Copyright ©The authors 2021
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