RT Journal Article
SR Electronic
T1 Increased ventilatory response to carbon dioxide in COPD patients following vitamin C administration
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00017-2015
DO 10.1183/23120541.00017-2015
VO 1
IS 1
A1 Sara E. Hartmann
A1 Christine K. Kissel
A1 Lian Szabo
A1 Brandie L. Walker
A1 Richard Leigh
A1 Todd J. Anderson
A1 Marc J. Poulin
YR 2015
UL http://openres.ersjournals.com/content/1/1/00017-2015.abstract
AB Patients with chronic obstructive pulmonary disease (COPD) have decreased ventilatory and cerebrovascular responses to hypercapnia. Antioxidants increase the ventilatory response to hypercapnia in healthy humans. Cerebral blood flow is an important determinant of carbon dioxide/hydrogen ion concentration at the central chemoreceptors and may be affected by antioxidants. It is unknown whether antioxidants can improve the ventilatory and cerebral blood flow response in individuals in whom these are diminished. Thus, we aimed to determine the effect of vitamin C administration on the ventilatory and cerebrovascular responses to hypercapnia during healthy ageing and in COPD.Using transcranial Doppler ultrasound, we measured the ventilatory and cerebral blood flow responses to hyperoxic hypercapnia before and after an intravenous vitamin C infusion in healthy young (Younger) and older (Older) subjects and in moderate COPD.Vitamin C increased the ventilatory response in COPD patients (mean (95% CI) 1.1 (0.9–1.1) versus 1.5 (1.1–2.0) L·min−1·mmHg−1, p<0.05) but not in Younger (2.5 (1.9–3.1) versus 2.4 (1.9–2.9) L·min−1·mmHg−1, p>0.05) or Older (1.3 (1.0–1.7) versus 1.3 (1.0–1.7) L·min−1·mmHg−1, p>0.05) healthy subjects. Vitamin C did not affect the cerebral blood flow response in the young or older healthy subjects or COPD subjects (p>0.05).Vitamin C increases the ventilatory but not cerebrovascular response to hyperoxic hypercapnia in patients with moderate COPD.Central chemosensitivity is increased after vitamin C infusion in COPD but not healthy young or older individuals http://ow.ly/Qf2TG