TY - JOUR T1 - The effect of adenotonsillectomy for childhood sleep apnoea on cardiorespiratory control JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00003-2016 VL - 2 IS - 2 SP - 00003-2016 AU - Mathias Baumert AU - Yvonne Pamula AU - James Martin AU - Declan Kennedy AU - Anand Ganesan AU - Muammar Kabir AU - Mark Kohler AU - Sarah A. Immanuel Y1 - 2016/04/01 UR - http://openres.ersjournals.com/content/2/2/00003-2016.abstract N2 - The efficacy of adenotonsillectomy for relieving obstructive sleep apnoea symptoms in children has been firmly established, but its precise effects on cardiorespiratory control are poorly understood.In 375 children enrolled in the Childhood Adenotonsillectomy Trial, randomised to undergo either adenotonsillectomy (n=194) or a strategy of watching waiting (n=181), respiratory rate, respiratory sinus arrhythmia and heart rate were analysed during quiet, non-apnoeic and non-hypopnoeic breathing throughout sleep at baseline and at 7 months using overnight polysomnography.Children who underwent early adenotonsillectomy demonstrated an increase in respiratory rate post-surgery while the watchful waiting group showed no change. Heart rate and respiratory sinus arrhythmia were comparable between both arms. On assessing cardiorespiratory variables with regard to normalisation of clinical polysomnography findings during follow-up, heart rate was reduced in children who had resolution of obstructive sleep apnoea syndrome, while no differences in their respiratory rate or respiratory sinus arrhythmia were observed.Adenotonsillectomy for obstructive sleep apnoea increases baseline respiratory rate during sleep. Normalisation of apnoea–hypopnoea index, spontaneously or via surgery, lowers heart rate. Considering the small average effect size, the clinical significance is uncertain.Adenotonsillectomy for childhood obstructive sleep apnoea increases respiratory rate during sleep http://ow.ly/Dptd300w9Pp ER -