TY - JOUR T1 - Cost-effectiveness of antibiotics for COPD management: observational analysis using CPRD data JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00085-2016 VL - 3 IS - 2 SP - 00085-2016 AU - Sarah J. Ronaldson AU - Anan Raghunath AU - David J. Torgerson AU - Tjeerd Van Staa Y1 - 2017/04/01 UR - http://openres.ersjournals.com/content/3/2/00085-2016.abstract N2 - It is often difficult to determine the cause of chronic obstructive pulmonary disease (COPD) exacerbations, and antibiotics are frequently prescribed. This study conducted an observational cost-effectiveness analysis of prescribing antibiotics for exacerbations of COPD based on routinely collected data from patient electronic health records.A cohort of 45 375 patients aged 40 years or more who attended their general practice for a COPD exacerbation during 2000–2013 was identified from the Clinical Practice Research Datalink. Two groups were formed (“immediate antibiotics” or “no antibiotics”) based on whether antibiotics were prescribed during the index general practice (GP) consultation, with data analysed according to subsequent healthcare resource use. A cost-effectiveness analysis was undertaken from the perspective of the UK National Health Service, using a time horizon of 4 weeks in the base case.The use of antibiotics for COPD exacerbations resulted in cost savings and an improvement in all outcomes analysed; i.e. GP visits, hospitalisations, community respiratory team referrals, all referrals, infections and subsequent antibiotics prescriptions were lower for the antibiotics group. Hence, the use of antibiotics was dominant over no antibiotics.The economic analysis suggests that use of antibiotics for COPD exacerbations is a cost-effective alternative to not prescribing antibiotics for patients who present to their GP, and remains cost-effective when longer time horizons of 3 months and 12 months are considered. It would be useful for a definitive trial to be undertaken in this area to determine the cost-effectiveness of antibiotics for COPD exacerbations.Prescribing antibiotics for patients presenting to their GP with COPD exacerbations was found to be cost-effective http://ow.ly/F7Pe30bYBEs ER -