RT Journal Article
SR Electronic
T1 Arterial stiffness in symptomatic smokers with normal lung function
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00037-2017
DO 10.1183/23120541.00037-2017
VO 3
IS 3
A1 Nicola Scichilone
A1 Antonino Tuttolomondo
A1 Carlo Maida
A1 Alida Benfante
A1 Jessica Peluso
A1 Anna Cirrincione
A1 Valerio Vassallo
A1 Antonio Pinto
YR 2017
UL http://openres.ersjournals.com/content/3/3/00037-2017.abstract
AB Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular morbidity and mortality. Arterial stiffness and endothelial dysfunction index are validated surrogate cardiovascular markers and are increased in subjects with COPD.We tested whether increased arterial stiffness and endothelial dysfunction occur in symptomatic smokers with no evidence of bronchial obstruction. Clinical and lung functional assessments were conducted in smoker subjects with chronic respiratory symptoms and in COPD patients. Pulse wave velocity (PWV), aortic augmentation index (AIx) and reactive hyperaemia index (RHI) were measured to estimate the cardiovascular risk.48 smokers (male n=37, female n=11; mean age 70±8.4 years) were studied. Smokers with respiratory symptoms without bronchial obstruction (n=13) did not differ from COPD patients (n=35) in terms of mean±sd PWV (12±3.2 m·s−1 versus 14±3.8 m·s−1; p=0.10), aortic AIx (25.2±11.8% versus 24.8±9.7%, p=0.89) and RHI (1.66±1.49 versus 1.62±1.43; p=0.79).The current investigation shows that the cardiovascular risk occurs in smokers with respiratory symptoms in the absence of bronchial obstruction. These findings need to be confirmed in larger populations in order to inform the design of intensive preventive programmes.Increased cardiovascular risk occurs in smokers with chronic respiratory symptoms and no airway obstruction http://ow.ly/7mes30cCxW5