TY - JOUR T1 - Importance of serial changes in biomarkers in idiopathic pulmonary fibrosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00019-2016 VL - 3 IS - 3 SP - 00019-2016 AU - Akihiko Sokai AU - Kiminobu Tanizawa AU - Tomohiro Handa AU - Kumiko Kanatani AU - Takeshi Kubo AU - Kohei Ikezoe AU - Yoshinari Nakatsuka AU - Shinsaku Tokuda AU - Toru Oga AU - Toyohiro Hirai AU - Sonoko Nagai AU - Kazuo Chin AU - Michiaki Mishima Y1 - 2017/07/01 UR - http://openres.ersjournals.com/content/3/3/00019-2016.abstract N2 - The clinical significance of serial changes in serum biomarkers in patients with idiopathic pulmonary fibrosis (IPF) remains to be established. This retrospective study was conducted to clarify the associations of serial changes in serum Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) with changes in physiological indices and overall mortality in IPF.The study subjects were 75 patients with IPF. The 6 month change in serum KL-6 was significantly correlated with changes in the percentage of the predicted forced vital capacity (FVC % pred) and the percentage of the predicted diffusing capacity of the lung for carbon monoxide (% DLCO), while the 6 month change in serum SP-D was correlated only with % DLCO. During the mean follow-up period of 647 days, 22 (29.3%) patients died. An increase in serum KL-6 over a 6 month period was a significant predictor of mortality even after adjustment for %FVC, % DLCO and serum KL-6 at the baseline (hazard ratio 1.10 per 100 U·mL−1, 95% CI 1.01–1.18, p=0.03), whereas the 6 month increase in serum SP-D was not significant.Serial measurements of serum KL-6 may provide additional prognostic information compared to that provided by physiological parameters in patients with IPF.Serial changes in serum KL-6 are associated with changes in physiological variables and can predict survival in IPF http://ow.ly/hCkb30eauLg ER -