TY - JOUR T1 - Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00092-2017 VL - 3 IS - 4 SP - 00092-2017 AU - Gennaro De Pascale AU - Otavio T. Ranzani AU - Saad Nseir AU - Jean Chastre AU - Tobias Welte AU - Massimo Antonelli AU - Paolo Navalesi AU - Eugenio Garofalo AU - Andrea Bruni AU - Luis Miguel Coelho AU - Szymon Skoczynski AU - Federico Longhini AU - Fabio Silvio Taccone AU - David Grimaldi AU - Helmut J.F. Salzer AU - Christoph Lange AU - Filipe Froes AU - Antoni Artigas AU - Emili Díaz AU - Jordi Vallés AU - Alejandro Rodríguez AU - Mauro Panigada AU - Vittoria Comellini AU - Luca Fasano AU - Paolo M. Soave AU - Giorgia Spinazzola AU - Charles-Edouard Luyt AU - Francisco Alvarez-Lerma AU - Judith Marin AU - Joan Ramon Masclans AU - Davide Chiumello AU - Angelo Pezzi AU - Marcus Schultz AU - Hafiz Mohamed AU - Menno Van Der Eerden AU - Roger A.S. Hoek AU - D.A.M.P.J. Gommers AU - Marta Di Pasquale AU - Rok Civljak AU - Marko Kutleša AU - Matteo Bassetti AU - George Dimopoulos AU - Stefano Nava AU - Fernando Rios AU - Fernando G. Zampieri AU - Pedro Povoa AU - Lieuwe D. Bos AU - Stefano Aliberti AU - Antoni Torres AU - Ignacio Martín-Loeches A2 - , Y1 - 2017/10/01 UR - http://openres.ersjournals.com/content/3/4/00092-2017.abstract N2 - The clinical course of intensive care unit (ICU) patients may be complicated by a large spectrum of lower respiratory tract infections (LRTI), defined by specific epidemiological, clinical and microbiological aspects.A European network for ICU-related respiratory infections (ENIRRIs), supported by the European Respiratory Society, has been recently established, with the aim at studying all respiratory tract infective episodes except community-acquired ones. A multicentre, observational study is in progress, enrolling more than 1000 patients fulfilling the clinical, biochemical and radiological findings consistent with a LRTI. This article describes the methodology of this study. A specific interest is the clinical impact of non-ICU-acquired nosocomial pneumonia requiring ICU admission, non-ventilator-associated LRTIs occurring in the ICU, and ventilator-associated tracheobronchitis. The clinical meaning of microbiologically negative infectious episodes and specific details on antibiotic administration modalities, dosages and duration are also highlighted. Recently released guidelines address many unresolved questions which might be answered by such large-scale observational investigations. In light of the paucity of data regarding such topics, new interesting information is expected to be obtained from our network research activities, contributing to optimisation of care for critically ill patients in the ICU.Methodology for the first European network for ICU-related respiratory infections (ENIRRIs) project http://ow.ly/sud930fU1e7 ER -