RT Journal Article
SR Electronic
T1 Decrease in pulmonary function and oxygenation after lung resection
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00055-2017
DO 10.1183/23120541.00055-2017
VO 4
IS 1
A1 Barbara Cristina Brocki
A1 Elisabeth Westerdahl
A1 Daniel Langer
A1 Domingos S.R. Souza
A1 Jan Jesper Andreasen
YR 2018
UL http://openres.ersjournals.com/content/4/1/00055-2017.abstract
AB Respiratory deficits are common following curative intent lung cancer surgery and may reduce the patient's ability to be physically active. We evaluated the influence of surgery on pulmonary function, respiratory muscle strength and physical performance after lung resection.Pulmonary function, respiratory muscle strength (maximal inspiratory/expiratory pressure) and 6-min walk test (6MWT) were assessed pre-operatively, 2 weeks post-operatively and 6 months post-operatively in 80 patients (age 68±9 years).Video-assisted thoracoscopic surgery was performed in 58% of cases. Two weeks post-operatively, we found a significant decline in pulmonary function (forced vital capacity −0.6±0.6 L and forced expiratory volume in 1 s −0.43±0.4 L; both p<0.0001), 6MWT (−37.6±74.8 m; p<0.0001) and oxygenation (−2.9±4.7 units; p<0.001), while maximal inspiratory and maximal expiratory pressure were unaffected. At 6 months post-operatively, pulmonary function and oxygenation remained significantly decreased (p<0.001), whereas 6MWT was recovered.We conclude that lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength. Future research should focus on mechanisms negatively influencing post-operative pulmonary function other than impaired respiratory muscle strength.Lung resection has a significant short- and long-term impact on pulmonary function and oxygenation, but not on respiratory muscle strength http://ow.ly/WTqc30h6j4i