RT Journal Article SR Electronic T1 Rationale and design of the screening of pulmonary hypertension in systemic lupus erythematosus (SOPHIE) study JF ERJ Open Research JO erjor FD European Respiratory Society SP 00135-2017 DO 10.1183/23120541.00135-2017 VO 4 IS 1 A1 Duo Huang A1 Yang-Yang Cheng A1 Pak-Hei Chan A1 Jojo Hai A1 Kai-Hang Yiu A1 Hung-Fat Tse A1 Ka-Lam Wong A1 Katherine Fan A1 Ying Wah Li A1 Woon-Leung Ng A1 Cheuk-Wan Yim A1 Cheuk-hon John Wong A1 Lai-Shan Tam A1 Priscilla C.H. Wong A1 Chi-Yuen Wong A1 Chup-Hei Ho A1 Alexander M.H. Leung A1 Chi-Chiu Mok A1 Ho Lam A1 Chak-Sing Lau A1 Tommy Cheung A1 Carmen Ho A1 Sharon W.Y. Law A1 Esther W. Chan A1 Li-Xue Yin A1 Wen-Sheng Yue A1 Toi Meng Mok A1 Mario Alberto Evora A1 Chung-Wah Siu YR 2018 UL http://openres.ersjournals.com/content/4/1/00135-2017.abstract AB Current guideline-recommended screening for pulmonary hypertension in patients with systemic sclerosis has not been evaluated in systemic lupus erythematosus (SLE), which is disproportionately prevalent in Asians.This multicentre, cross-sectional screening study aims to study the prevalence of pulmonary hypertension among SLE patients using these guidelines, and identify independent predictors and develop a prediction model for pulmonary hypertension in SLE patients.SLE patients from participating centres will undergo an echocardiography- and biomarker-based pulmonary hypertension screening procedure as in the DETECT study. Standard right heart catheterisation will be provided to patients with intermediate or high echocardiographic probability of pulmonary hypertension. Those with low echocardiographic probability will rescreen within 1 year. The primary measure will be the diagnosis and types of pulmonary hypertension and prevalence of pulmonary hypertension in SLE patients. The secondary measures will be the predictors and prediction models for pulmonary hypertension in SLE patients. The estimated sample size is approximately 895 participants.The results of the SOPHIE study will be an important contribution to the literature of SLE-related pulmonary hypertension and may be immediately translatable to real clinical practice. Ultimately, this study will provide the necessary evidence for establishing universal guidelines for screening of pulmonary hypertension in SLE patients.Screening pulmonary hypertension among SLE patients: SOPHIE study http://ow.ly/3iS930hlNPw