TY - JOUR T1 - Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00071-2017 VL - 4 IS - 1 SP - 00071-2017 AU - Taizou Hirano AU - Shinya Ohkouchi AU - Naoki Tode AU - Makoto Kobayashi AU - Manabu Ono AU - Teruyuki Satoh AU - Yoichiro Mitsuishi AU - Akira Watanabe AU - Masao Tabata AU - Toshiya Irokawa AU - Hiromasa Ogawa AU - Hisatoshi Sugiura AU - Toshiaki Kikuchi AU - Keiichi Akasaka AU - Ryushi Tazawa AU - Yoshikazu Inoue AU - Koh Nakata AU - Hajime Kurosawa AU - Masakazu Ichinose Y1 - 2018/01/01 UR - http://openres.ersjournals.com/content/4/1/00071-2017.abstract N2 - Autoimmune pulmonary alveolar proteinosis (aPAP) is caused by an excess of autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). In this situation, the clearance of intracellular debris in alveolar macrophages is impaired, and the alveolar spaces are occupied by excessive surfactant sediments. Several serum markers (lactate dehydrogenase (LDH), KL-6, carcinoembryonic antigen and surfactant protein D), alveolar–arterial oxygen difference (PA–aO2) and the percentage diffusing capacity of the lung for carbon monoxide (%DLCO) have a correlation with the disease severity and are used to evaluate the severity of aPAP [1].Nitric oxide and alveolar macrophage inflammation http://ow.ly/czCx30i12n8 ER -