RT Journal Article SR Electronic T1 Randomised controlled trial of cognitive behavioural therapy in COPD JF ERJ Open Research JO erjor FD European Respiratory Society SP 00094-2018 DO 10.1183/23120541.00094-2018 VO 4 IS 4 A1 Heslop-Marshall, Karen A1 Baker, Christine A1 Carrick-Sen, Debbie A1 Newton, Julia A1 Echevarria, Carlos A1 Stenton, Chris A1 Jambon, Michelle A1 Gray, Joanne A1 Pearce, Kim A1 Burns, Graham A1 De Soyza, Anthony YR 2018 UL http://openres.ersjournals.com/content/4/4/00094-2018.abstract AB Anxiety is an important comorbidity in chronic obstructive pulmonary disease (COPD). We investigated if cognitive behavioural therapy (CBT), delivered by respiratory nurses, reduced symptoms of anxiety and was cost-effective.Patients with COPD and anxiety were randomised to CBT or self-help leaflets. Anxiety, depression and quality of life were measured at baseline, 3, 6 and 12 months. A cost-effectiveness analysis was conducted from a National Health Service hospital perspective and quality-adjusted life-years estimated using the EuroQol-5D questionnaire.In total, 279 patients were recruited. Group mean change from baseline to 3 months in the Hospital Anxiety and Depression Anxiety Subscale was 3.4 (95% CI 2.62–4.17, p<0.001) for the CBT group and 1.88 (95% CI 1.19–2.55, p<0.001) in the leaflet group. The CBT group was superior to leaflets at 3 months (mean difference in the Hospital Anxiety and Depression Anxiety Subscale was 1.52, 95% CI 0.49–2.54, p=0.003). Importantly, the CBT intervention was more cost-effective than leaflets at 12 months, significantly lowering hospital admissions and attendance at emergency departments.CBT delivered by respiratory nurses is a clinically and cost-effective treatment for anxiety in patients with COPD relative to self-help leaflets.Cognitive behavioural therapy (CBT) delivered by respiratory nurses is clinically effective and cost-effective for patients with chronic obstructive pulmonary disease and symptoms of anxiety http://ow.ly/o41o30msBNy