RT Journal Article SR Electronic T1 Prospective observational study in patients with obstructive lung disease: NOVELTY design JF ERJ Open Research JO erjor FD European Respiratory Society SP 00036-2018 DO 10.1183/23120541.00036-2018 VO 5 IS 1 A1 Reddel, Helen K. A1 Gerhardsson de Verdier, Maria A1 Agustí, Alvar A1 Anderson, Gary A1 Beasley, Richard A1 Bel, Elisabeth H. A1 Janson, Christer A1 Make, Barry A1 Martin, Richard J. A1 Pavord, Ian A1 Price, David A1 Keen, Christina A1 Gardev, Asparuh A1 Rennard, Stephen A1 Sveréus, Alecka A1 Bansal, Aruna T. A1 Brannman, Lance A1 Karlsson, Niklas A1 Nuevo, Javier A1 Nyberg, Fredrik A1 Young, Simon S. A1 Vestbo, Jørgen YR 2019 UL http://openres.ersjournals.com/content/5/1/00036-2018.abstract AB Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features and share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD and asthma–COPD overlap are limited. NOVELTY is a global, prospective observational 3-year study enrolling ∼12 000 patients ≥12 years of age from primary and specialist clinical practices in 19 countries (ClinicalTrials.gov identifier: NCT02760329).NOVELTY's primary objectives are to describe patient characteristics, treatment patterns and disease burden over time, and to identify phenotypes and molecular endotypes associated with differential outcomes over time in patients with a diagnosis/suspected diagnosis of asthma and/or COPD. NOVELTY aims to recruit real-world patients, unlike clinical studies with restrictive inclusion/exclusion criteria.Data collected at yearly intervals include clinical assessments, spirometry, biospecimens, patient-reported outcomes (PROs) and healthcare utilisation (HCU). PROs and HCU will also be collected 3-monthly via internet/telephone. Data will be used to identify phenotypes and endotypes associated with different trajectories for symptom burden, clinical progression or remission and HCU. Results may allow patient classification across obstructive lung disease by clinical outcomes and biomarker profile, rather than by conventional diagnostic labels and severity categories.NOVELTY will provide a rich data source on obstructive lung disease, to help improve patient outcomes and aid novel drug development.NOVELTY is a global study to characterise patients with asthma and/or COPD and identify novel phenotypes and endotypes http://ow.ly/QFiH30n3IBF