RT Journal Article
SR Electronic
T1 How does the GINA definition of control correlate with quality of life and sputum cellularity?
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00146-2018
DO 10.1183/23120541.00146-2018
VO 5
IS 1
A1 Marcia Margaret Menezes Pizzichini
A1 Cristiane Cinara Rocha
A1 Michelle Gonçalves de Souza Tavares
A1 Leila John Marques Steidle
A1 Rosemeri Maureci da Silva
A1 Felipe dal Pizzol
A1 Peter G. Gibson
A1 Emilio Pizzichini
YR 2019
UL http://openres.ersjournals.com/content/5/1/00146-2018.abstract
AB Since 2014, the Global Initiative for Asthma (GINA) has stated that asthma control should be measured using four questions concerning diurnal and nocturnal symptoms, activity limitation, and rescue medication use. We assessed how asthma control by this definition correlates with airway inflammation and quality of life.113 asthmatic subjects consecutively recruited from their routine clinical appointment underwent spirometry, sputum induction and answered the Standardised Asthma Quality of Life Questionnaire (AQLQ(S)) during a single visit.43 (38.1%), 37 (32.7%) and 33 (29.2%) subjects had controlled asthma, partly controlled asthma and uncontrolled asthma, respectively. The majority of subjects with controlled asthma (67.4%) had paucigranulocytic sputum. Eosinophilic sputum was present in all levels of asthma control. Although most subjects with controlled asthma (58.1%) achieved an AQLQ(S) score ≥6 (minimal or no impairment), the remaining patients (41.9%) had moderate/some impairment (AQLQ(S) score <6 and ≥3) due to activity impairment and environmental exposure.The present GINA definition of current symptom control reflects control of airway inflammation. However, quality of life impairment can be present even in these patients. Measuring quality of life may provide useful information when evaluating asthma control.Quality of life impairment can be present even in patients with controlled asthma and controlled airway inflammation http://ow.ly/RCmz30n4EUT