TY - JOUR T1 - Does the multiple-breath washout test need to be measured before spirometry? JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00230-2018 VL - 5 IS - 1 SP - 00230-2018 AU - Jacky W.Y. Au AU - Reginald McDonald AU - Sanja Stanojevic AU - Felix Ratjen Y1 - 2019/02/01 UR - http://openres.ersjournals.com/content/5/1/00230-2018.abstract N2 - The multiple-breath washout (MBW) test is commonly used as an outcome measure in research studies, and evidence is accumulating in support of its clinical utility to identify early lung disease and monitor disease progression. At present, the MBW test is combined with traditional pulmonary function tests, such as spirometry. Forced expiratory manoeuvres may have the effect of mobilising secretions and could affect distribution of ventilation; therefore, MBW is conventionally performed prior to spirometry. In infants with lung disease, forced expiratory manoeuvres using the raised volume rapid thoracoabdominal compression technique were associated with a significant decrease in the lung clearance index (LCI) [1].Spirometry does not have a short-term effect on multiple-breath washout outcomes, thus allowing greater flexibility for implementation into clinical practice http://ow.ly/2Tg330ngXk4 ER -