RT Journal Article
SR Electronic
T1 Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00014-2019
DO 10.1183/23120541.00014-2019
VO 5
IS 1
A1 William W. Siljan
A1 Jan C. Holter
A1 Annika E. Michelsen
A1 Ståle H. Nymo
A1 Trine Lauritzen
A1 Kjersti Oppen
A1 Einar Husebye
A1 Thor Ueland
A1 Tom E. Mollnes
A1 Pål Aukrust
A1 Lars Heggelund
YR 2019
UL http://openres.ersjournals.com/content/5/1/00014-2019.abstract
AB Background Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis in community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) and calprotectin levels, and plasma pentraxin 3 (PTX3) and presepsin levels, along with whole-blood white cell counts, at three time-points, and examined their association with microbial aetiology and adverse clinical outcomes in CAP.Methods Blood samples were obtained at hospital admission, clinical stabilisation and 6-week follow-up from 267 hospitalised adults with CAP. Adverse short-term outcome was defined as intensive care unit admission and 30-day mortality. Long-term outcome was evaluated as 5-year all-cause mortality.Results Peak levels of all biomarkers were seen at hospital admission. Increased admission levels of C-reactive protein, PCT and calprotectin were associated with bacterial aetiology of CAP, while increased admission levels of PCT, PTX3 and presepsin were associated with adverse short-term outcome. In univariate and multivariate regression models, white blood cells and calprotectin at 6-week follow-up were predictors of 5-year all-cause mortality.Conclusions Calprotectin emerges as both a potential early marker of bacterial aetiology and a predictor for 5-year all-cause mortality in CAP, whereas PCT, PTX3 and presepsin may predict short-term outcome.In 267 adults with community-acquired pneumonia, systemic calprotectin emerges as an early marker of bacterial aetiology and a predictor of 5-year mortality, whereas systemic procalcitonin, pentraxin 3 and presepsin are predictors of short-term outcome http://ow.ly/dz6S30nAFvn