@article {Mylius00056-2018, author = {Caspar Frederik Mylius and Wilhelmus Petrus Krijnen and Cornelis Peter van der Schans and Tim Takken}, editor = {, and Wittink, Harriet and Schmitz, Marcel and van Ooi, Pieter-Jan and van Beek, Geert and van Galen, Leendert and Molinger, Jeroen and Rozenberg, Robert and van den Oord, Marieke and Hartman, Yvonne and Verbaarschot, Nicolle and Snoek, Aernout and Stomphorst, Jaap and van Kesteren, Joep}, title = {Peak oxygen uptake reference values for cycle ergometry for the healthy Dutch population: data from the LowLands Fitness Registry}, volume = {5}, number = {2}, elocation-id = {00056-2018}, year = {2019}, doi = {10.1183/23120541.00056-2018}, publisher = {European Respiratory Society}, abstract = {Peak oxygen uptake (V'O2peak) is recognised as the best expression of aerobic fitness. Therefore, it is essential that V'O2peak reference values are accurate for interpreting a cardiopulmonary exercise test (CPET). These values are country specific and influenced by underlying biological ageing processes. They are normally stratified per paediatric and adult population, resulting in a discontinuity at the transition point between prediction equations. There are currently no age-related reference values available for the lifespan of individuals in the Dutch population. The aim of this study is to determine the best-fitting regression model for V'O2peak in the healthy Dutch paediatric and adult populations in relation to age.In this retrospective study, CPET cycle ergometry results of 4477 subjects without reported somatic diseases were included (907 females, age 7.9{\textendash}65.0 years). Generalised additive models were employed to determine the best-fitting regression model. Cross-validation was performed against an independent dataset consisting of 3518 subjects (170 females, age 6.8{\textendash}59.0 years).An additive model was the best fitting with the largest predictive accuracy in both the primary (adjusted R2=0.57, standard error of the estimate (see)=556.50 mL{\textperiodcentered}min-1) and cross-validation (adjusted R2=0.57, see=473.15 mL{\textperiodcentered}min-1) dataset.This study provides a robust additive regression model for V'O2peak in the Dutch population.Peak oxygen uptake has a nonlinear dependence on years of age in the paediatric and adult Dutch populations http://ow.ly/H3fH30nIjRy}, URL = {https://openres.ersjournals.com/content/5/2/00056-2018}, eprint = {https://openres.ersjournals.com/content/5/2/00056-2018.full.pdf}, journal = {ERJ Open Research} }