TY - JOUR T1 - Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00010-2019 VL - 5 IS - 2 SP - 00010-2019 AU - Össur Ingi Emilsson AU - Shadi Amid Hägg AU - Eva Lindberg AU - Karl A. Franklin AU - Kjell Toren AU - Bryndis Benediktsdottir AU - Thor Aspelund AU - Francisco Gómez Real AU - Bénédicte Leynaert AU - Pascal Demoly AU - Torben Sigsgaard AU - Jennifer Perret AU - Andrei Malinovschi AU - Deborah Jarvis AU - Judith Garcia-Aymerich AU - Thorarinn Gislason AU - Christer Janson A2 - , Y1 - 2019/04/01 UR - http://openres.ersjournals.com/content/5/2/00010-2019.abstract N2 - Introduction The study aim was to examine the association of snoring and nocturnal gastro-oesophageal reflux (nGOR) with respiratory symptoms and lung function, and if snoring and/or nGOR associated with a steeper decline in lung function.Methods Data from the third visit of the European Community Respiratory Health Survey (ECRHS) was used for cross-sectional analysis. Pre- and post-bronchodilator spirometry was performed, and information on sleep, nGOR and respiratory symptoms was collected (n=5715). Habitual snoring and nGOR were assessed by questionnaire reports. Pre-bronchodilator spirometry from ECRHS I, II and III (20 years follow-up) were used to analyse lung function changes by multivariate regression analysis.Results Snoring and nGOR were independently associated with a higher prevalence of wheeze, chest tightness, breathlessness, cough and phlegm. The prevalence of any respiratory symptom was 79% in subjects with both snoring and nGOR versus 56% in those with neither (p<0.001). Subjects with both snoring and nGOR had more frequent exacerbations (adjusted prevalence 32% versus 19% among “no snoring, no nGOR”, p=0.003). Snoring but not nGOR was associated with a steeper decline in forced expiratory volume in 1 s over 10 years after adjusting for confounding factors (change in % predicted −5.53, versus −4.58 among “no snoring”, p=0.04) and forced vital capacity (change in % predicted −1.94, versus −0.99 among “no snoring”, p=0.03).Conclusions Adults reporting both habitual snoring and nGOR had more respiratory symptoms and more frequent exacerbations of these symptoms. Habitual snoring was associated with a steeper decline in lung function over time.Middle-aged adults with habitual snoring have a steeper decline in lung function over 10 years compared to controls. Habitual snorers with nocturnal gastro-oesophageal reflux have a higher prevalence of nocturnal respiratory symptoms than controls. http://ow.ly/YsiK30odcMY ER -