RT Journal Article
SR Electronic
T1 Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00010-2019
DO 10.1183/23120541.00010-2019
VO 5
IS 2
A1 Össur Ingi Emilsson
A1 Shadi Amid Hägg
A1 Eva Lindberg
A1 Karl A. Franklin
A1 Kjell Toren
A1 Bryndis Benediktsdottir
A1 Thor Aspelund
A1 Francisco Gómez Real
A1 Bénédicte Leynaert
A1 Pascal Demoly
A1 Torben Sigsgaard
A1 Jennifer Perret
A1 Andrei Malinovschi
A1 Deborah Jarvis
A1 Judith Garcia-Aymerich
A1 Thorarinn Gislason
A1 Christer Janson
A1 ,
YR 2019
UL http://openres.ersjournals.com/content/5/2/00010-2019.abstract
AB Introduction The study aim was to examine the association of snoring and nocturnal gastro-oesophageal reflux (nGOR) with respiratory symptoms and lung function, and if snoring and/or nGOR associated with a steeper decline in lung function.Methods Data from the third visit of the European Community Respiratory Health Survey (ECRHS) was used for cross-sectional analysis. Pre- and post-bronchodilator spirometry was performed, and information on sleep, nGOR and respiratory symptoms was collected (n=5715). Habitual snoring and nGOR were assessed by questionnaire reports. Pre-bronchodilator spirometry from ECRHS I, II and III (20 years follow-up) were used to analyse lung function changes by multivariate regression analysis.Results Snoring and nGOR were independently associated with a higher prevalence of wheeze, chest tightness, breathlessness, cough and phlegm. The prevalence of any respiratory symptom was 79% in subjects with both snoring and nGOR versus 56% in those with neither (p<0.001). Subjects with both snoring and nGOR had more frequent exacerbations (adjusted prevalence 32% versus 19% among “no snoring, no nGOR”, p=0.003). Snoring but not nGOR was associated with a steeper decline in forced expiratory volume in 1 s over 10 years after adjusting for confounding factors (change in % predicted −5.53, versus −4.58 among “no snoring”, p=0.04) and forced vital capacity (change in % predicted −1.94, versus −0.99 among “no snoring”, p=0.03).Conclusions Adults reporting both habitual snoring and nGOR had more respiratory symptoms and more frequent exacerbations of these symptoms. Habitual snoring was associated with a steeper decline in lung function over time.Middle-aged adults with habitual snoring have a steeper decline in lung function over 10 years compared to controls. Habitual snorers with nocturnal gastro-oesophageal reflux have a higher prevalence of nocturnal respiratory symptoms than controls. http://ow.ly/YsiK30odcMY