RT Journal Article SR Electronic T1 Memory, attention and fluency deficits in COPD may be a specific form of cognitive impairment JF ERJ Open Research JO erjor FD European Respiratory Society SP 00229-2018 DO 10.1183/23120541.00229-2018 VO 5 IS 2 A1 Charlotte Morris A1 James W. Mitchell A1 Hannah Moorey A1 Helen-Cara Younan A1 George Tadros A1 Alice M. Turner YR 2019 UL http://openres.ersjournals.com/content/5/2/00229-2018.abstract AB There is increasing evidence demonstrating an association between chronic obstructive pulmonary disease (COPD) and cognitive impairment. We present a narrative review of published studies on the subject and a cross-sectional study investigating domain-specific cognitive impairment in people with COPD compared to people with known Alzheimer's dementia, and controls without known COPD or cognitive impairment. The aim of the study was to compare prevalence and pattern of cognitive impairment between the three groups using the Addenbrooke's Cognitive Examination (ACE)-III tool.A total of 89 participants were recruited (44 with COPD, 17 with Alzheimer's and 28 controls).Patients with COPD had significantly lower total ACE-III scores than controls (p<0.001). When comparing the COPD group to the known Alzheimer's dementia group, overall ACE-III scores were significantly lower in the Alzheimer's dementia group than the COPD group (p=0.019). The domain-specific scores for attention (p<0.004), memory (p<0.004) and fluency (p<0.001) were significantly lower in the Alzheimer's dementia group than the COPD group.Our result suggest that the COPD group were significantly more likely to have cognitive impairment than the healthy control group. This was supported by the results of a narrative review of the published literature. Our results show that the pattern of impairment in the COPD group is different to the pattern of impairment shown in the known Alzheimer's dementia group, with significant differences in the cognitive domains affected. These results are in keeping with the findings of other previously published studies included in the narrative review.People with COPD are more likely than controls to have cognitive impairment. When compared to people with known Alzheimer's disease, the pattern of impairment and cognitive domains affected are significantly different. http://bit.ly/2VPFxjh