TY - JOUR T1 - The superexacerbator phenotype in patients with COPD: a descriptive analysis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00235-2018 VL - 5 IS - 2 SP - 00235-2018 AU - Lowie E.G.W. Vanfleteren AU - Lotte M.C. Boonen AU - Martijn A. Spruit AU - Daisy J.A. Janssen AU - Emiel F.M. Wouters AU - Frits M.E. Franssen Y1 - 2019/04/01 UR - http://openres.ersjournals.com/content/5/2/00235-2018.abstract N2 - Exacerbations are pivotal events in the natural history of chronic obstructive pulmonary disease (COPD), as they contribute to quality-of-life impairment, disease progression, hospitalisations and mortality [1–4]. Therefore, exacerbation prevention is one of the major goals in the management of patients with COPD, although a subgroup of patients with optimal treatment may still experience exacerbations [5].The superexacerbator is highly prevalent in patients with COPD entering rehabilitation and these patients have worse disease overall http://bit.ly/30q2k7M ER -