RT Journal Article
SR Electronic
T1 Comparison of intrapleural use of urokinase and tissue plasminogen activator/DNAse in pleural infection
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00084-2019
DO 10.1183/23120541.00084-2019
VO 5
IS 3
A1 Benoît Bédat
A1 Jérôme Plojoux
A1 Jade Noel
A1 Anna Morel
A1 Jonathan Worley
A1 Frédéric Triponez
A1 Wolfram Karenovics
YR 2019
UL http://openres.ersjournals.com/content/5/3/00084-2019.abstract
AB Fibrinolysis can be used to improve fluid drainage in pleural infection. Treatment with either urokinase or tissue plasminogen activator (t-PA) in association with DNAse via a chest tube has been effective at reducing the need for surgery. This study is the first to compare the efficacy of these two treatments.We performed a single-centre, controlled, prospective cohort study. All individuals with pleural infection admitted to our hospital between January 2014 and December 2017 who were treated with antibiotics, a chest tube and fibrinolysis were included in this study. The rate of additional procedure requirements (additional chest tube or surgery) after initial fibrinolysis, complications, costs, and radiological and biological outcomes were analysed.Among the 93 patients included in this study, 34% required additional procedures after an initial fibrinolysis, including 21% who received an additional chest tube and 13% who underwent thoracoscopy. The need for additional procedures arose due to presence of multiple pleural collections (p=0.01) and was associated with the use of large-bore drain (p=0.01). The success rate of fibrinolysis was not significantly different between urokinase and t-PA/DNAse (p=0.35). The differences in drainage duration and in length of hospital stay were not significant either (p=0.05 and p=0.12, respectively). Treatment with t-PA/DNAse was cheaper (p=0.04) but was associated with a higher rate of haemothorax (p=0.002).In conclusion, treatment with urokinase is safer and equally effective when compared with treatment with t-PA/DNAse.In pleural infection, the efficacy of pleural drainage is comparable between high doses of urokinase and tissue plasminogen activator/DNAse http://bit.ly/2lHuxat