PT  - JOURNAL ARTICLE
AU  - Javier Leonardo Galindo
AU  - Adriana Catalina Galeano
AU  - David Alfonso Suarez-Zamora
AU  - Ana Milena Callejas
AU  - Mónica Patricia Caicedo-Verástegui
AU  - Darío Londoño
AU  - Luis Gerardo García-Herreros
AU  - Aylen Vanessa Ospina-Serrano
AU  - Alfredo Saavedra
AU  - Plutarco Garcíaherreros
AU  - Diana María Palacios
AU  - Margarita Baldión
TI  - Comparison of the QuantiFERON-TB and tuberculin skin test for detection of latent tuberculosis infection in cancer patients in a developing country
AID  - 10.1183/23120541.00258-2018
DP  - 2019 Oct 01
TA  - ERJ Open Research
PG  - 00258-2018
VI  - 5
IP  - 4
4099  - http://openres.ersjournals.com/content/5/4/00258-2018.short
4100  - http://openres.ersjournals.com/content/5/4/00258-2018.full
SO  - erjor2019 Oct 01; 5
AB  - Cancer patients have an increased risk of reactivation of latent tuberculosis infection. It is unknown which strategy on screening should be used in this population in developing countries. We aimed to determine the concordance between the tuberculin skin test (TST) and QuantiFERON®-TB (QFT) assay in order to diagnose latent tuberculosis infection in cancer patients.We conducted a cross-sectional study of the agreement of diagnostic tests. Prevalence and agreement between tests were calculated. A logistic regression to assess predictors of discordance was performed. The accuracy of the TST to predict QFT results by a receiver operating characteristic (ROC) curve was evaluated.We included 149 adults with cancer without active tuberculosis. Prevalence of latent tuberculosis infection was 21.5% (n=32), defined as positive results on either test. Test agreement was moderate for the diagnosis of latent tuberculosis infection (κ=0.43, 90% CI 0.26–0.6). No predictor was associated with the chance of discordant results. Agreement improved slightly using a cut-off point ≥8 mm (κ=0.5, 90% CI 0.35–0.66).In a moderate-incidence setting, a moderate agreement was found between tests in cancer patients. Modification of the cut-off points of test results achieved marginally better agreement between the TST and QFT.QuantiFERON and tuberculin skin test have a moderate agreement for latent tuberculosis infection diagnosis in cancer patients. Modifying cut-off points may improve agreement of tests. http://bit.ly/32bNwLc