RT Journal Article
SR Electronic
T1 Parental and life-course influences on symptomatic airflow obstruction
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00343-2019
DO 10.1183/23120541.00343-2019
VO 6
IS 1
A1 Lok Sze Katrina Li
A1 Marie T. Williams
A1 Kylie N. Johnston
A1 Peter Frith
A1 Elina Hyppönen
A1 Catherine Paquet
YR 2020
UL http://openres.ersjournals.com/content/6/1/00343-2019.abstract
AB Few studies have examined the contribution of life-course factors in explaining familial aggregation of chronic lung conditions. Using data from the 1958 British Birth Cohort, a life-course approach was used to examine whether, and how, exposure to risk factors through one's life explained the association between parental respiratory disease history and symptomatic airflow obstruction (AO). Cohort participants (n=6212) were characterised in terms of parental respiratory disease history and symptomatic AO at 45 years. Life-course factors (e.g. smoking, asthma and early-life factors) were operationalised as life period-specific and cumulative measures. Logistic regression and path analytic models predicting symptomatic AO adjusted for parental respiratory disease history were used to test different life-course models (critical period, accumulation- and chain-of-risks models). While some life-course factors (e.g. childhood passive smoking and occupational exposure) were individually associated with parental respiratory disease history and symptomatic AO, asthma (OR 6.44, 95% CI 5.01–8.27) and persistent smoking in adulthood (OR 5.42, 95% CI 4.19–7.01) had greater impact on the association between parental respiratory disease history and symptomatic AO. A critical period model provided a better model fit compared with an accumulation-of-risk model and explained 57% of the effect of parental respiratory disease history on symptomatic AO. Adulthood asthma and smoking status explained around half of the effect of parental respiratory disease history on chronic obstructive pulmonary disease. Beyond smoking history, the combination of parental respiratory disease history and adulthood asthma may provide an opportunity for early diagnosis and intervention.Adulthood asthma and smoking explain half of the effect of parental respiratory disease history on symptomatic airflow obstruction. Use of a life-course approach and models may help clarify mechanisms behind associations in intergenerational lung health. http://bit.ly/2PIzGf4