TY - JOUR T1 - Pubertal-onset overweight and COPD in men: a cohort study JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00326-2019 VL - 6 IS - 1 SP - 00326-2019 AU - Sara Tengvall AU - Claes Ohlsson AU - Maria Bygdell AU - Jari Martikainen AU - Anders Andersson AU - Jenny M. Kindblom Y1 - 2020/01/01 UR - http://openres.ersjournals.com/content/6/1/00326-2019.abstract N2 - A global obesity epidemic has occurred among both adults and children during the last three decades [1]. Among patients with chronic obstructive pulmonary disease (COPD), low body mass index (BMI) is associated with poor prognosis and excess mortality [2], while obesity appears protective [3], a phenomenon known as the obesity paradox. Still, in milder forms of COPD, obesity is associated with increased risk of mortality, possibly mediated via the strong association with diabetes and hypertension [4]. Furthermore, abdominal fat accumulation is the strongest predictor of lung function impairment [5], and abdominal circumference is almost twice as high in COPD patients as in sex- and age-matched controls [6]. Thus, previous studies on the relationship between BMI and COPD have evaluated the associations for adult BMI, while it is unknown if BMI during childhood or adolescence, i.e. many years before onset of COPD, predicts the development of COPD later in life.Men who develop overweight specifically during puberty (i.e. normal weight at age 8, overweight at age 20 years) have 70% increased risk of COPD as adults compared to men without overweight http://bit.ly/2TradZA ER -