TY - JOUR T1 - Assessment of non-invasive ventilation in acute severe asthma patients JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.28 VL - 6 IS - suppl 4 SP - 28 AU - Mohamed M. Metwally AU - Olfat Elshinnawy AU - Nermeen Abdelaleem AU - Walaa Mokhtar Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/28.abstract N2 - Background: Despite improvements in asthma medications, Intubation is deemed necessary in severe asthma with its complications. Non-invasive ventilation is the evolving method to manage acute respiratory failure in these patients.Aims: To assess the effect of NIV in acute severe asthma patients.Design: Two years of a prospective interventional study.Methods: Patients with acute severe asthma were classified into two groups. group 1 received standard medical therapy and group 2 received the same plus NIV. Patients’ demographics, physiological, functional data and ABGs were recorded. The primary outcomes were the improvement in FEV1, ABGs, HR and RR. The secondary outcomes were the assessment of the need for invasive MV, ICU stay and hospital stay.Results: Ninety patients with acute severe asthma (57 females and 33 males, mean ± SD age 52 ± 15.7 ys, FEV1% predicted mean ± SD 42.7± 13%, RR 30.52±3,7, HR 127.68±9.1 and PaO2 57.78±10.21 mmHg). There was a significant improvement after 6 hours in RR (16.6 ± 3.7), HR (95.8 ± 11.3), and PaO2 (88.09 ± 20.2). After 1h and 24 hours, more than 50% improvement in FEV1 was significantly more in the NIV group. The time needed to alleviate accessory muscle use was significantly shorter in group 2 (mean ± SD 1.93 ± 0.3 hours) than in group 1 (mean ± SD 3.07 ± 0.4hours) with a P value =0.027. The failure rate was more with group1 (4 patients needed intubation, but only 2 patients in group 2). There was no mortality in any group of our study. There were shorter ICU and hospital stay in NIV group. fig. 1&2Conclusion: The use of NIV was effective in improving oxygenation, lung function, shorten the length of ICU and hospital stay in acute severe asthma patients.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 28.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -