TY - JOUR T1 - The estimated cost of chronic obstructive pulmonary disease exacerbation in intensive care unit JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.43 VL - 6 IS - suppl 4 SP - 43 AU - Amira Jamoussi AU - Laaroussi Safouene Saula AU - Takoua Merhebene AU - Samia Ayed AU - Jalila Ben Khelil AU - Mohamed Besbes Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/43.abstract N2 - Background: COPD represents a major public health problem worldwide because of its high prevalence and socio-economic repercussions. In Tunisia, few studies focused on the burden of this disease.We aimed to estimate the cost of ICU hospitalization due to COPD exacerbation; then to investigate higher cost associated factors.Methods: This retrospective study included all patients admitted in ICU) of Abderrahmen Mami hospital for COPD exacerbation, between, January 1st and December 31, 2016. We estimated of the cost of the hospitalization based on all prescribed laboratory tests, treatments, consumable necessary for their use as well as all complementary examinations and explorations carried out during the ICU-stay. An univariate analysis was performed to determine higher cost associated factors. The estimated cost was expressed in Tunisian dinars(TND) and in Euros(€) according to change course in 2016 (1€=2.43 TND).Results: We included 190 patients aged of 67±11 years and 85% of them was men. All patients had an acute respiratory failure, 40 of them were in coma and 14 were in shock. The mean length of ICU stay was 9.2 ± 9 days.The mean cost of COPD exacerbation hospitalisation in ICU was 2471±2517 TND(1017±1036€). The daily mean cost per patient was 333±210 TND(137±86€). Total expenses in 2016 for COPD exacerbation in ICU was 469735 TND(193307€).Higher mean cost associated factors were: need to invasive mechanical ventilation (3505TND vs 1370TND;p<10-3) and one or more complication (4161TND vs 1242TND;p<10-3).Conclusions: The estimated cost of exacerbations of COPD in intensive care is very high.To reduce these costs, optimization of non-invasive ventilation should be promoted.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 43.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -