TY - JOUR T1 - Ventilatory management in acute respiratory failure of patients with obesity-hypoventilation syndrome JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.36 VL - 6 IS - suppl 4 SP - 36 AU - Amira Jamoussi AU - Racha Ghabara AU - Ameni Khaled AU - Samia Ayed AU - Jalila Ben Khelil AU - Mohamed Besbes Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/36.abstract N2 - Background: Non-invasive ventilation (NIV) is widely considered during management of acute respiratory failure within obesity-hypoventilation syndrome(OHS) patients in ICU. Nevertheless, other management features remain debated.We aimed to describe ventilatory practices and outcome of SOH patients in intensive care unit.Methods: This was a retrospective study carried within a medical ICU in Abderrahmen Mami Hospital between January 2017 and September 2019. OHS Patients admitted in ICU were included. Ventilatory management and outcomes were collected.Results: We enrolled 55 patients. Mean age was 64±11 years and sex-ratio=1.04. At their basic state, patients had primarily chronic respiratory failure with mMRC dyspnoea stage of 2(47%) and 3(33%).At admission, 53(96%) patients had acute respiratory failure, 40(75%) were hypercapnic. At arterial blood gases, means pH, PaCO2 and PaO2/FiO2 were respectively 7.29±0.12; 63±23 mmHg and 182±95 mmHg.NIV was used as first-line ventilatory support in 43 subjects (78%) and was successful in 30(70%). PEP max setting was 10cmH2O and mean NIV duration was 4.5±3days.Invasive ventilation (n=25) was immediately necessary in 12 patients and secondary in the 13 others.Mechanical ventilation weaning was processed in 21 patients (38,2 %), it was simple (n=5), difficult (n=11) or prolonged (n=5). Extubation was scheduled in 8 cases and accidental in 4 cases.Mean length of stay was 12±11days. Overall mortality was 40%. It was 21 % in NIV success group, 67% within immediately intubated patients, and reached 85% in intubated patients after NIV failure.Conclusion: NIV success within OHS patients was 70%. Invasively ventilated patients had poor outcome.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 36.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -