TY - JOUR T1 - Effects of BMI on clinical outcomes in acute respiratory failure requiring invasive mechanical ventilation JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.20 VL - 6 IS - suppl 4 SP - 20 AU - Omar Mahmoud AU - Bing Chen AU - Abhishek Chakraborti Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/20.abstract N2 - Background: in certain acute conditions, obesity has been shown to reduce in-hospital mortality (the obesity paradox). The aim of this study is to analyze the association between different classes of body max index (BMI) and in-hospital mortality, weaning failure and subsequent need for tracheostomy, length of stay and total hospital charge in patients admitted for acute respiratory failure (ARF) requiring invasive mechanical ventilation.Methods: we conducted a retrospective analysis of patients included in the 2016 National Inpatient Sample (NIS). We divided the patients into 13 groups according to their BMI. A multivariate analysis was conducted to adjust for age, gender, race, hospital characteristics, presence of malnutrition and critical care illness, and Charlson comorbidity index.Results: obesity was associated with reduced in-hospital mortality but increased need for tracheostomy when BMI>40. Obesity was also associated with increased LOS (when BMI>40) and hospital cost.Conclusions: In mechanically ventilated patients, obesity is associated with reduced mortality, increased need for tracheostomy, LOS and hospital charge.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 20.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -