TY - JOUR T1 - In vitro aerosol delivery by vibrating mesh nebulizer (VMN) and pressurized metered dose inhaler (pMDI) using spacers in comparison with T adapters in mechanical ventilation. JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.47 VL - 6 IS - suppl 4 SP - 47 AU - Myriam Eckes AU - Alice Paris AU - Brenda Hervieu AU - Alison Vanlaeys AU - Karim Housseini AU - Thierry Porée Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/47.abstract N2 - In vitro performance of spacers were evaluated in comparison with T adapters in adult and paediatric mechanical ventilation models.With the ventilator set in volume controlled (VC) mode with adult breathing parameters, aerosol delivery by pMDI (Ventolin, GSK) was compared when using a spacer (CombiHaler®, Laboratoire optimHal-ProtecSom; Aerochamber MV®, AeroVent® and Aerochamber Mini®, Trudell Medical) instead of a T adapter (Intersurgical). Aerosol delivery by nebulization was compared when using a spacer instead of a T adapter (Aeroneb Solo® T piece, Aerogen).With the ventilator set in VC mode with peadiatric breathing parameters (corresponding to a child of 15kg weight), aerosol delivery by pMDI was compared when using a spacer (MinimHal®, Laboratoire OptimHal-ProtecSom) instead of a MDI adapter (Intersurgical) and aerosol delivery by nebulization was compared when using a spacer (MinimHal®) instead of a T adapter (Aeroneb Solo® peadiatric T piece).Using the adult model, Aerosol delivery by nebulization increased when using the spacer (42.75 ± 4.48 % vs 35.26 ± 7.44 %). Aerosol delivery by pMDI increased up to two or three-fold when using the spacer instead of an MDI adapter.Using the peadiatric model, aerosol delivery by nebulization was higher with the spacer than with the T piece (23.84 ± 7.72 % 15.06 ± 4.18 %). Aerosol delivery by pMDI increased by up to three-fold when using the spacer in comparison to the T adapter (9.45 ± 2.27 % vs 2.94 ± 0.34%).In this in vitro study, using a spacer instead of a T adapter with both a pMDI and a VMN increased drug delivery.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 47.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -