PT  - JOURNAL ARTICLE
AU  - Gavin Bennett
AU  - Paul Mckiernan
AU  - Mary Joyce
AU  - Amy Tatham
AU  - Ronan Macloughlin
TI  - Effect of tidal volume and nebuliser position on aerosol delivery during neonate ventilation
AID  - 10.1183/23120541.RFMVC-2020.44
DP  - 2020 Feb 13
TA  - ERJ Open Research
PG  - 44
VI  - 6
IP  - suppl 4
4099  - http://openres.ersjournals.com/content/6/suppl_4/44.short
4100  - http://openres.ersjournals.com/content/6/suppl_4/44.full
SO  - erjor2020 Feb 13; 6
AB  - Introduction: Concurrent delivery of aerosolised therapeutics is commonly prescribed during neonatal mechanical ventilation. Neonates present unique challenges for aerosol therapy due to their low tidal volumes, rapid breathing and small airways and interfaces. The objective of this study was to evaluate the effect of tidal volume and nebuliser position on aerosol delivery during simulated neonatal mechanical ventilation.Methods: A ventilator (Maquet Servo I, Getinge, Germany) (Vt 5mL and 10mL, 60BPM, I:E 1:2) in combination with a 2.5mm endotracheal tube (ETT) and humidified circuit was used. 2000µg of Salbutamol was nebulised using the Aerogen Solo (Aerogen, Ireland) and lung dose was assessed across four nebuliser positions within the circuit. Lung dose was quantified by UV spectroscopy at 276 nm, following elution of drug captured at the distal end of the endotracheal tube.Results View this table:Table 1. Mean ± standard deviation values of lung dose (µg).Conclusions: Increasing tidal volume was associated with a greater lung dose, with the exception of placing the nebuliser before the Wye. However, this difference was only observed to be statistically significant when the nebuliser was placed at the wet side of the humidifier. Consistent with previous reports, the position of the nebuliser between the wye and ETT was shown to have the most significant effect on lung dose during neonatal mechanical ventilation, at both tidal volumes.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 44.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).