TY - JOUR T1 - How long should clinicians wait to stop a trial of humidified oxygen via high flow nasal cannula in "de novo" respiratory failure? JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.10 VL - 6 IS - suppl 4 SP - 10 AU - Lígia Helena Pires Vicente AU - Joao Estevao AU - Pedro Americano AU - Daniela Silva AU - Gloria Cabral Campello Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/10.abstract N2 - Background: The use of humidified oxygen via high flow nasal cannula (HFNC) to treat "de novo" respiratory failure (DRF) is potential alternative to non-invasive mechanical ventilation (NIV). The best timing to evaluate efficacy is still in discussion.Aim: To investigate the impact of timing in success after starting HFNC in DRF patients versus non invasive ventilation (NIV).Methods: Retrospective study, patients aged 18 years or more, admitted in the Intensive Care Department with DRF diagnosis and submitted to HFNC or NIV therapy according to the attending physician's criteria, fRespiratory rate (RR), pH, paCO2, paO2 and the need for intubation were assessed at 4, 12 and 24 hours after HFNC or NIV. Exclusion criteria: hipercapnia (paCO2>45mmHg) on admission, pulmonary fibrosis, immunossuppressed patients and therapeutic limitation to entubation.Results: Twenty-four patients were enrolled, 13 in the HFNC group and 11 in the NIV group. Average age 61.6 HFNC group, 73.1 NIV group. At 4 hours of treatment was the time when the highest decrease in RR values was observed in both groups. This was also the timing for the higher rates of entubation. In this time interval, the improvement of PH and PaCO2 values was significantly more evident in the HFNC group (p= 0.03 and p= 0.04). In relation to Oxygenation the timing of 24h was when occurred the best improvement in both groups, but was higher in HFNC group.Conclusions: The timing for stop the trial in this group of patients were the 4 hours, but the sucesseful patients had the highest improvement of paO2 24h after HFNC.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 10.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -