TY - JOUR T1 - Impact of the phosphatidylcholine treatment program on the respiratory failure in patients with community-acquird pneumonia JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.53 VL - 6 IS - suppl 4 SP - 53 AU - Olga Shtepa Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/53.abstract N2 - The aim of our study was to estimate the impact of the phosphatidylchline treatment program (PHTP) on the respiratory failure and the plasma surfactant protein D (SPD) levels in patients (pts) with community-acquird pneumonia (CAP) during the antibacterial therapy (ABT).We observed 58 pts with CAP and 10 healthy persons (H). They made the study samples. All pts with CAP were divided into groups: the first one (1st) - 35 pts with CAP on protocol treatment, the second (2d) - 23 pts with CAP on the PHTP in addition to ABT. Plasma SPD levels and the oxygen saturation of hemoglobin in arterial blood were measured on the first, third and tenth days of the admission to the hospital in adition to general examination and standard diagnostic program. The PHTP: seven-day therapy, the aerosol delivery of liposome was carried out by nebulization.The SPD levels in both groups were significantly higher on the third day then on the first day and decrease on tenth day (p<0,05). But on the third and the ten days the SPD levels were statisticaly lower in the 2d group then in the 1st one (p<0,05). There were significant difference between SPD levels in the 1st group and H (p<0,05). The levels of the oxygen saturation in both groups were lower on the first day of admission, but it indreasing were statisticaly faster in the 2d group (p<0,05). There were the statisticaly negative correlation between SPD levels and oxygen saturation (R=-0,56, p<0,05).The PHTP increased the oxygen saturation, decreased the SPD levels mach better compare to the standart  treatment program and got mach faster improvement of the clinical symptoms of respiratory failure in pts with CAP.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 53.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -