PT  - JOURNAL ARTICLE
AU  - Khaled Hussein
AU  - Gamal Rabie
TI  - Non invasive proportional assist ventilation versus pressure support ventilation in management of acute  respiratory failure of COPD
AID  - 10.1183/23120541.RFMVC-2020.30
DP  - 2020 Feb 13
TA  - ERJ Open Research
PG  - 30
VI  - 6
IP  - suppl 4
4099  - http://openres.ersjournals.com/content/6/suppl_4/30.short
4100  - http://openres.ersjournals.com/content/6/suppl_4/30.full
SO  - erjor2020 Feb 13; 6
AB  - Proportional assist ventilation (PAV) is hypothesized to have better comfort, less airway pressure, less likelihood of over ventilation, and  better triggering and synchrony.Objective: To compare between the effect of non invasive  proportional assist ventilation and pressure support ventilation in-patients with acute hypercapnic respiratory failure due to acute exacerbation of COPD.Patients & methods: Thirty six patients were offered enrollment into the study if they had acute hypercapnic respiratory failure due to acute exacerbation of COPD despite standard medical treatment. Patients were categorized into two groups of equal number, PSV group, and PAV group, according to if they submitted for S/T, or PAV/T mode respectively. Patients were fitted with an oronasal  mask (Comfort full  Mask, Respironics, Inc)  connected to BiPAP vision ventilator (Respironics Inc, Murrysville PA).Results:  A total of 26 patients (72.2 %) were managed successfully with non invasive ventilation (NIV); 12 in PSV group, and 14 in PAV group.Both groups show significant (P<0.01) improvement after 1h NIV  in pH , PaCO2, and O2 saturation.A significant lower values (P<0.01) regarding Ti/Ttot and peak inspiratory pressure ( PIP) were observed in successful PAV group. Also there is a significant (P<0.001) better triggering after 30 min. in PAVgroup (89.9 ± 1.3) vs (77 ± 5.4) in PSV group.No significant dfference in ICU stay between both groups.Conclusion: Both non invasive PSV and PAV can reduce respiratory effort, and improve gas exchange in acute hypercapnic respiratory failure due to COPD. PAV is preferred for patients with good triggering, otherwise PSV should be used.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 30.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).