TY - JOUR T1 - Assessing symptom burden and depression in patients with chronic respiratory insufficiency. JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.37 VL - 6 IS - suppl 4 SP - 37 AU - Heidi Rantala AU - Sirpa Leivo-Korpela AU - Anni Hanhimäki AU - Lauri Lehtimäki AU - Juho T Lehto Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/37.abstract N2 - Background: Patients with chronic respiratory insufficiency (CRI) suffer from many symptoms and also from depression, but the symptom burden and screening tools are poorly described.Aims and objectives: To describe symptom burden in patients with CRI using Edmonton Symptom Assessment System (ESAS) and to find out whether the depression question in ESAS could serve as a screening tool for depression.Methods: We evaluated symptoms in 226 patients with CRI using ESAS questionnaire measuring symptoms on a scale from 0 (no symptoms) to 10 (worst possible symptom) and Depression scale (DEPS) questionnaire in which the cut-off point for depression is 9.Results: ESAS scores in pain at rest was 1.0 (IQR 0.0-3.0), pain at movement 3.0 (0.0-6.0), tiredness 3.0 (1.0-6.0), shortness of breath 4.0 (1.0-7.0), loss of appetite 0.0 (0.0-3.0), nausea 0.0 (0.0-1.0), dry mouth 3.0 (1.0-7.0), constipation 1.0 (0.0-3.0), depression 1.0 (0.0-3.0), anxiety 1.0 (0.0-3.0), insomnia 2.0 (0.0-4.0) and well-being 4.0 (2.0-5.0). Patients with COPD had considerably more severe symptoms in shortness of breath, dry mouth and loss of appetite in contrast to patients with other diseases causing CRI. Patients with DEPS≥9 had significantly more severe symptoms in all ESAS categories compared to those patients with DEPS<9. Area under the ROC-curve for ESAS depression score predicting DEPS≥9 was 0.840(P<0.001). ESAS depression score <2 had a negative predictive value of 85% and ≥4 had a positive predictive value of 89% for DEPS≥9.Conclusions: Patients with CRI suffer from a high symptom burden and it increases with depression. Four points in the depression question in ESAS should lead to more close examination of depression.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 37.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -