TY - JOUR T1 - Nasal humidified high flow oxygen prolongs endurance exercise in interstitial lung disease. JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.12 VL - 6 IS - suppl 4 SP - 12 AU - Frédéric Hérengt AU - Daniel Veale AU - Yara Al Chikhanie AU - Samuel Vergès Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/12.abstract N2 - Introduction: Despite subnormal blood gases at rest, patients with interstitial lung disease manifest precipitous oxygen desaturation on effort often with severe breathlessness. High Flow Heated and Humidified Oxygen (HFHHO²) via adapted nasal cannulae may increase effort capacity and duration.Methods: We compared cycling endurance in ambient air (AA), with conventional oxygen (O²) and with HFHHO² in interstitial lung disease patients.Results: At this stage of the study, 10 patients with established interstitial lung disease (6 male, 4 female) mean age 74 years, mean PaO² in air (7.6 kPa) underwent 3 exercise tests a 70% maximum workload on a cycle ergometer. Oxygen was delivered at 4 l/min, and HFHHO² via Airvo © system with FiO² at 50%, humidified at 100% and with positive pressure nasal cannulae (approx. 3 cm H²0).All patients had a significantly longer endurance with oxygen (median 367.5 sec) vs AA (median 161 sec) and endurance was increased further with HFHHO² (median 612.5 sec) compared to the two other conditions.Cardiorespiratory responses and dyspnea during exercise were significantly improved with HFHHO² compared to AA and O².Conclusion: HFHHO² significantly improves endurance cycling in severe interstitial lung disease and may permit such patients to better benefit from endurance training in rehabilitation programs.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 12.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -