RT Journal Article
SR Electronic
T1 Nasal humidified high flow oxygen prolongs endurance exercise in interstitial lung disease.
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 12
DO 10.1183/23120541.RFMVC-2020.12
VO 6
IS suppl 4
A1 Frédéric Hérengt
A1 Daniel Veale
A1 Yara Al Chikhanie
A1 Samuel Vergès
YR 2020
UL http://openres.ersjournals.com/content/6/suppl_4/12.abstract
AB Introduction: Despite subnormal blood gases at rest, patients with interstitial lung disease manifest precipitous oxygen desaturation on effort often with severe breathlessness. High Flow Heated and Humidified Oxygen (HFHHO²) via adapted nasal cannulae may increase effort capacity and duration.Methods: We compared cycling endurance in ambient air (AA), with conventional oxygen (O²) and with HFHHO² in interstitial lung disease patients.Results: At this stage of the study, 10 patients with established interstitial lung disease (6 male, 4 female) mean age 74 years, mean PaO² in air (7.6 kPa) underwent 3 exercise tests a 70% maximum workload on a cycle ergometer. Oxygen was delivered at 4 l/min, and HFHHO² via Airvo © system with FiO² at 50%, humidified at 100% and with positive pressure nasal cannulae (approx. 3 cm H²0).All patients had a significantly longer endurance with oxygen (median 367.5 sec) vs AA (median 161 sec) and endurance was increased further with HFHHO² (median 612.5 sec) compared to the two other conditions.Cardiorespiratory responses and dyspnea during exercise were significantly improved with HFHHO² compared to AA and O².Conclusion: HFHHO² significantly improves endurance cycling in severe interstitial lung disease and may permit such patients to better benefit from endurance training in rehabilitation programs.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 12.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).