TY - JOUR T1 - Impact of the duration of renal replacement therapy on the respiratory complications in patients with end-stage renal disease JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.RFMVC-2020.46 VL - 6 IS - suppl 4 SP - 46 AU - Olga Shtepa AU - Oleksandr Kuryata AU - Olha Halushchak Y1 - 2020/02/13 UR - http://openres.ersjournals.com/content/6/suppl_4/46.abstract N2 - The aim of our study was to evaluate the raspiratory complications and changes in the parameters of the function of external respiration in patients (pts) with end-stage renal disease on the replacement therapy.Materials and metods: All pts were divided into groups: I group included 24 pts  with end-stage renal disease and the duration of replacement therapy under five years, II group - 26 pts with end-stage renal disease and the duration over ten years. Control group – 12 almost healthy persons. Laboratory blood tests of hematological parameters, renal function tests, pulse oximetry and spirometry tests were performed in addition to standard diagnostic program.Results: There were a significant difference (p˂0.05) in patients of the first and second groups between the indicators of the vital capacity maximal (72 [71-90]% and 65 [62-76]%), forced vital capacity in the first second (86 [85-92]% and 79 [77-89]%), peak expiratory flow (80 [64-91]% and 69 [64-80]%), maximal mid-expiratory flow 25%–75% (76 [66-98]% and 68 [65-72]%) and the oxygen saturation levels (p˂0.05). This parameters were statistically lower relative to the control group.The duration of replacement therapy was negatively correlated with spirometric parameters: vital capacity maximal (R=-0,54; p˂0.05), forced vital capacity in the first second (R=-0,62; p˂0.05), peak expiratory flow (R=-0,46; p˂0.05), maximal midexpiratory flow (R=-0,47; p˂0.05).Conclusions: The raspiratory complications are common among patients with end-stage renal disease and become the cause of chronic respiratory failure. The respiratory abnormalities is closely associated with increasing substitution treatment period.FootnotesCite this article as: ERJ Open Research 2020; 6: Suppl. 4, 46.This is an ERS Respiratory Failure and Mechanical Ventilation Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -