RT Journal Article
SR Electronic
T1 Virus, allergic sensitisation and cortisol in infant bronchiolitis and risk of early asthma
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00268-2019
DO 10.1183/23120541.00268-2019
VO 6
IS 1
A1 Jon Olav Gjengstø Hunderi
A1 Leif Bjarte Rolfsjord
A1 Karin C. Lødrup Carlsen
A1 René Holst
A1 Egil Bakkeheim
A1 Teresa Løvold Berents
A1 Kai-Håkon Carlsen
A1 Håvard Ove Skjerven
YR 2020
UL http://openres.ersjournals.com/content/6/1/00268-2019.abstract
AB Background Acute bronchiolitis during infancy and human rhinovirus (HRV) lower respiratory tract infections increases the risk of asthma in atopic children. We aimed to explore whether specific viruses, allergic sensitisation or cortisol levels during acute bronchiolitis in infancy increase the risk of early asthma, using recurrent wheeze as a proxy.Methods In 294 children with a mean (range) age of 4.2 (0–12) months enrolled during hospitalisation for acute infant bronchiolitis, we analysed virus in nasopharyngeal aspirates, serum specific immunoglobulin E against food and inhalant allergens, and salivary morning cortisol. These factors were assessed by regression analyses, adjusted for age, sex and parental atopy, for risk of recurrent wheeze, defined as a minimum of three parentally reported episodes of wheeze at the 2-year follow-up investigation.Results At 2 years, children with, compared to without, recurrent wheeze had similar rates of respiratory syncytial virus (RSV) (82.9% versus 81.8%) and HRV (34.9% versus 35.0%) at the acute bronchiolitis, respectively. During infancy, 6.9% of children with and 9.2% of children without recurrent wheeze at 2 years were sensitised to at least one allergen (p=0.5). Neither recurrent wheeze nor incidence rate ratios for the number of wheeze episodes at 2 years were significantly associated with specific viruses, high viral load of RSV or HRV, allergic sensitisation, or morning salivary cortisol level during acute bronchiolitis in infancy.Conclusion In children hospitalised with acute infant bronchiolitis, specific viruses, viral load, allergic sensitisation and salivary morning cortisol did not increase the risk of early asthma by 2 years of age.In infants with acute bronchiolitis, specific viruses including human rhinovirus, viral load and/or allergic sensitisation did not increase the risk of asthma by 2 years of age. http://bit.ly/2tCE9Yd