TY - JOUR T1 - Lack of evidence for the involvement of Merkel cell polyomavirus in pulmonary Langerhans cell histiocytosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00230-2019 VL - 6 IS - 2 SP - 00230-2019 AU - Fanélie Jouenne AU - Jérôme Le Goff AU - Emmanuelle Bugnet AU - Maud Salmona AU - Véronique Meignin AU - Gwenaël Lorillon AU - Aurélie Sadoux AU - Janine Cherot AU - Céleste Lebbé AU - Samia Mourah AU - Abdellatif Tazi Y1 - 2020/04/01 UR - http://openres.ersjournals.com/content/6/2/00230-2019.abstract N2 - Langerhans cell histiocytosis (LCH) is currently considered a rare neoplastic disease with an inflammatory component, driven by genomic alterations in the mitogen-activating protein kinase (MAPK) pathway, including BRAFV600E, MAP2K1 mutations and BRAF deletions [1, 2]. Lung involvement is frequently observed in adult LCH patients, almost exclusively in young smokers of both sexes [3]. The aetiology of LCH, including pulmonary LCH (PLCH), remains unknown. A viral triggering factor of LCH has long been suspected, but the results of studies are inconclusive [4, 5].Compared to control lung tissues from smokers, MCPyV DNA is rarely detected in PLCH lesions and is not associated with alterations of the MAPK pathway. A viral trigger in PLCH pathogenesis remains elusive. https://bit.ly/2xKmkIoThe authors thank S. Mercier-Delarue for performing plasmid experiments (Infectious Agents Dept, Virology Unit, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France) and M. Mao (Pulmonology Dept, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France) for her technical assistance. ER -