@article {Ott00334-2019, author = {Sebastian R. Ott and Francesco Fanfulla and Silvia Miano and Thomas Horvath and Andrea Seiler and Corrado Bernasconi and Carlo W. Cereda and Anne-Kathrin Brill and Peter Young and Lino Nobili and Mauro Manconi and Claudio L.A. Bassetti}, editor = {,}, title = {SAS Care 1: sleep-disordered breathing in acute stroke and transient ischaemic attack {\textendash} prevalence, evolution and association with functional outcome at 3 months, a prospective observational polysomnography study}, volume = {6}, number = {2}, elocation-id = {00334-2019}, year = {2020}, doi = {10.1183/23120541.00334-2019}, publisher = {European Respiratory Society}, abstract = {Sleep-disordered breathing (SDB) is frequent in patients with acute stroke. Little is known, however about the evolution of SDB after stroke. Most of our knowledge stems from smaller cohort studies applying limited cardiopulmonary sleep recordings or from cross-sectional data collected in different populations.This study aims to determine prevalence, type and intra-individual evolution of SDB based on full-night polysomnography (PSG) in acute stroke and 3 months thereafter. Furthermore, we aimed to identify predictors of SDB in the acute and chronic phase and to evaluate associations between SDB and functional outcome at 3 months (M3).A total of 166 patients with acute cerebrovascular events were evaluated by full PSG at baseline and 105 again at M3. The baseline prevalence of SDB (apnoea{\textendash}hypopnoea index (AHI)\>5{\textperiodcentered}h-1) was 80.5\% and 25.4\% of the patients had severe SDB (AHI\>30{\textperiodcentered}h-1). Obstructive sleep apnoea was more prevalent than central sleep apnoea (83.8\% versus 13\%). Mean{\textpm}SD AHI was 21.4{\textpm}17.6{\textperiodcentered}h-1and decreased significantly at M3 (18{\textpm}16.4{\textperiodcentered}h-1; p=0.018). At M3, 91\% of all patients with baseline SDB still had an AHI\>5{\textperiodcentered}h-1 and in 68.1\% the predominant type of SDB remained unchanged (78.9\% in obstructive sleep apnoea and 44.4\% in central sleep apnoea). The only predictors of SDB at baseline were higher age and body mass index and in the chronic phase additionally baseline AHI. Baseline AHI was associated with functional outcome (modified Rankin score \>3) at M3.The high prevalence of SDB in acute stroke, its persistence after 3 months, and the association with functional outcome supports the recommendation for a rapid SDB screening in stroke patients.The high prevalence of SDB in acute stroke, its persistence after 3 months and its association with functional outcome support the recommendation for rapid SDB screening in stroke patients https://bit.ly/3bFWqV7}, URL = {https://openres.ersjournals.com/content/6/2/00334-2019}, eprint = {https://openres.ersjournals.com/content/6/2/00334-2019.full.pdf}, journal = {ERJ Open Research} }