RT Journal Article
SR Electronic
T1 Serum periostin reflects dynamic hyperinflation in patients with asthma
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00347-2019
DO 10.1183/23120541.00347-2019
VO 6
IS 2
A1 Takamitsu Asano
A1 Hiroyuki Ohbayashi
A1 Mitsue Ariga
A1 Osamu Furuta
A1 Sahori Kudo
A1 Junya Ono
A1 Kenji Izuhara
YR 2020
UL http://openres.ersjournals.com/content/6/2/00347-2019.abstract
AB Introduction Dynamic hyperinflation (DH) is sometimes observed and is associated with impaired daily life activities of asthma. We assessed the relationship between DH and asthma biomarkers (blood eosinophil, fractional exhaled nitric oxide (FeNO) and serum periostin) in patients with asthma.Methods Fifty patients with stable asthma were prospectively recruited and underwent blood test, FeNO measurement, spirometry and metronome-paced tachypnoea (MPT) test to assess DH. In MPT tests, inspiratory capacity (IC) was measured at baseline and after 30 s of MPT with breathing frequencies of 20, 30 and 40 breaths·min−1. DH was assessed by the decline of IC from baseline, and maximal IC reduction ≥10% was considered as positive DH.Results Thirty patients (60%) showed positive DH. Patients with positive DH showed higher serum periostin levels (107.0±30.7 ng·mL−1) than patients with negative DH (89.7±23.7) (p=0.04). Patients in Global Initiative for Asthma treatment steps 4–5 (n=19) showed higher serum periostin levels (p=0.01) and more severe IC reduction after MPT (p<0.0001) than patients in steps 1–3 (n=31). Maximal IC reduction after MPT was significantly correlated with asthma control test score (r=−0.28, p=0.05), forced expiratory volume in 1 s (r=−0.56, p<0.0001), and serum periostin levels (r=0.41, p=0.003).Conclusion Serum periostin may have the possibility to reflect DH in patients with stable asthma.Serum periostin level as a marker of dynamic hyperinflation in patients with asthma https://bit.ly/3djKTeQ