RT Journal Article
SR Electronic
T1 The opposite effect of human leukocyte antigen genotypes in sarcoidosis and tuberculosis: a narrative review of the literature
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00155-2020
DO 10.1183/23120541.00155-2020
VO 6
IS 3
A1 Anna Malkova
A1 Anna Starshinova
A1 Yulia Zinchenko
A1 Natalia Basantsova
A1 Vera Mayevskaya
A1 Piotr Yablonskiy
A1 Yehuda Shoenfeld
YR 2020
UL http://openres.ersjournals.com/content/6/3/00155-2020.abstract
AB Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics that make some researchers consider a common pathogenesis for these diseases. Human leukocyte antigen (HLA) genotypes are studied both in sarcoidosis and tuberculosis patients, but to our knowledge, there are no comparative studies of genetic predisposition for sarcoidosis and tuberculosis development.The aim of this review was to analyse the relationship between HLA genotypes and the development of sarcoidosis and tuberculosis. Original and review articles published in various online databases from 1960 to 2019 were studied.The search results showed opposite effects of the HLA genotypes on predisposition to sarcoidosis or tuberculosis. It was revealed that the genotypes predisposing to the development of sarcoidosis (HLA-DRB1*03/07/15) have protective properties against the development of tuberculosis. Moreover, genotypes causing the development of tuberculosis (HLA-DRB1*04) have a protective effect on the development of sarcoidosis.The results of this narrative review of the literature may allude to the existence of genetic predispositions that lead to the development of an antibacterial or autoimmune response to mycobacteria.The HLA-DRB1*03/07/15 genotypes predispose to the development of sarcoidosis and have protective properties against the development of tuberculosis, while the HLA-DRB1*04 genotype has an opposite effect on the development of these diseases https://bit.ly/2Tl2rj1