PT - JOURNAL ARTICLE AU - Pau Benito AU - Sergo Vashakidze AU - Shota Gogishvili AU - Keti Nikolaishvili AU - Albert Despuig AU - Nestan Tukvadze AU - Natalia Shubladze AU - Zaza Avaliani AU - Cristina Vilaplana TI - Impact of adjuvant therapeutic surgery on the health-related quality of life of pulmonary tuberculosis patients AID - 10.1183/23120541.00083-2020 DP - 2020 Jul 01 TA - ERJ Open Research PG - 00083-2020 VI - 6 IP - 3 4099 - http://openres.ersjournals.com/content/6/3/00083-2020.short 4100 - http://openres.ersjournals.com/content/6/3/00083-2020.full SO - erjor2020 Jul 01; 6 AB - This study aimed to determine the health-related quality of life (HRQoL) of patients with pulmonary tuberculosis (TB) and to assess its change after a therapeutic surgical procedure. In this scenario, the purpose was to elucidate and quantify the effect of various demographic, epidemiological, clinical, surgical and psychosocial details on this variable.A prospective cohort of 40 patients undergoing therapeutic surgery for pulmonary TB (Study of Human Tuberculosis Lesions (SH-TBL) cohort) was recruited in Tbilisi, Georgia, between 2016 and 2018. HRQoL was assessed by administering the St George's Respiratory Questionnaire (SGRQ) and a novel psychosocial questionnaire, the BCN-Q, both at baseline and at 6 months post-surgery.A statistically and clinically significant improvement in the SGRQ total score was observed at follow-up, although it did not reach the values found for the healthy population. The differences between time points were statistically significant for the following groups: women, age <40 years, body mass index ≥20 kg·m−2, nonsmokers, drug-susceptible and drug-resistant participants, both new and relapsed patients, early culture negativisation, cases with a single lesion, either lesions <35 mm or ≥35 mm, and lesion, lobe and lung resections.The analysis of BCN-Q together with the SGRQ showed that several of its items, such as marital status, living conditions, nutrition, employment, external support, certain attitudes towards the healthcare system, emotional burden and sleep troubles, can impact HRQoL.These results highlight the benefit of adjuvant therapeutic surgery for pulmonary TB in selected patients in terms of HRQoL and suggest that a comprehensive approach including demographic, epidemiological, clinical and psychosocial variables may more accurately predict TB evolution and prognosis.Adjuvant therapeutic surgery in selected pulmonary TB patients improves their health-related quality of life. Impact of psychosocial variables on HRQoL may be assessed using a newly developed questionnaire, namely BCN-Q. https://bit.ly/2A169rR