TY - JOUR T1 - Managing COPD with expiratory or inspiratory pressure load training based on a prolonged expiration pattern JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00041-2020 VL - 6 IS - 3 SP - 00041-2020 AU - Keisuke Miki AU - Kazuyuki Tsujino AU - Mari Miki AU - Kenji Yoshimura AU - Hiroyuki Kagawa AU - Yohei Oshitani AU - Kiyoharu Fukushima AU - Takanori Matsuki AU - Yuji Yamamoto AU - Hiroshi Kida Y1 - 2020/07/01 UR - http://openres.ersjournals.com/content/6/3/00041-2020.abstract N2 - Background Exertional prolonged expiration should be identified as a therapeutic target in COPD. The efficacy of expiratory or inspiratory pressure load training (EPT/IPT) based on the degree of prolonged expiration was investigated.Methods A total of 21 patients with COPD were divided into two groups according to the exertional change in the inspiratory duty cycle (TI/Ttot). For 12 weeks, patients whose exertional TI/Ttot decreased received EPT (EPT group, n=11, mean percentage forced expiratory volume in 1 s (%FEV1), 32.8%) and those whose exertional TI/Ttot increased received IPT (IPT group, n=10, mean %FEV1, 45.1%).Results The therapeutic responses were as follows. In both groups, endurance time (EPT, +5.7 min, p<0.0001; IPT, +6.1 min, p=0.0004) on the constant work rate exercise test (WRET) and peak oxygen uptake increased (EPT, p=0.0028; IPT, p=0.0072). In the EPT group the following occurred: 1) soon after commencement of exercise with the constant WRET, the expiratory tidal volume (VTex) increased, reducing dyspnoea; 2) VTex and mean expiratory flow increased and then prolonged expiration (p=0.0001) improved at peak exercise with the incremental exercise test (ET); and 3) St. George's Respiratory Questionnaire total, activity and impact scores were improved. In the IPT group, on both the constant WRET and incremental ET, breathing frequency increased, which led to greater exercise performance with effort dyspnoea.Conclusions This study showed the benefits of EPT/IPT on exercise performance. If the choice of managing COPD with EPT/IPT is appropriate, inexpensive EPT/IPT may become widespread as home-based training.Expiratory or inspiratory pressure load training (EPT/IPT) based on the degree of prolonged expiration improves exercise performance in COPD patients. If managing COPD with EPT/IPT is chosen appropriately, it could become widespread as home-based training. https://bit.ly/2ZWutWq ER -