TY - JOUR T1 - Short-term survival of ARDS patients due to influenza virus infection alone: a cohort study JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00587-2020 SP - 00587-2020 AU - Arnaud Gacouin AU - Mathieu Lesouhaitier AU - Florian Reizine AU - Charlotte Pronier AU - Murielle Grégoire AU - Benoit Painvin AU - Adel Maamar AU - Vincent Thibault AU - Yves Le Tulzo AU - Jean Marc Tadié Y1 - 2020/01/01 UR - http://openres.ersjournals.com/content/early/2020/09/01/23120541.00587-2020.abstract N2 - Rationale Influenza virus (IV)-related pathophysiology suggests that the prognosis of ARDS due to IV could be different from the prognosis of ARDS due to other causes. However, the impact of IV infection alone on the prognosis of ARDS patients compared to that of patients with other causes of ARDS has been poorly assessed.Methods We compared the 28-day survival from the diagnosis of ARDS with a PaO2/FiO2 ≤150 mmHg between patients with and without IV infection alone. Data were collected prospectively and analysed retrospectively. We first performed survival analysis on the whole population; second, patients with IV infection alone were compared with matched pairs using propensity score matching.Main Results The cohort admitted from October 2009 to March 2020 comprised 572 patients, including 73 patients (13%) with IV alone. On the first 3 days of mechanical ventilation, nonpulmonary Sequential Organ Failure Assessment (SOFA) scores were significantly lower in patients with IV infection than in the other patients. After the adjusted analysis, IV infection alone remained independently associated with lower mortality at day 28 (hazard ratio: 0.51; 95% confidence interval: 0.26–0.99, p=0.047). Mortality at day 28 was significantly lower in patients with IV infection alone than in other patients when propensity score matching was used (20% versus 38%, p=0.02).Conclusions Our results suggest that patients with ARDS following IV infection alone have a significantly better prognosis at day 28 and less severe nonpulmonary organ dysfunction than do those with ARDS from causes other than IV infection alone.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Gacouin has nothing to disclose.Conflict of interest: Dr. LESOUHAITIER has nothing to disclose.Conflict of interest: Dr. reizine has nothing to disclose.Conflict of interest: Dr. Pronier has nothing to disclose.Conflict of interest: Dr. Grégoire has nothing to disclose.Conflict of interest: Dr. Painvin has nothing to disclose.Conflict of interest: Dr. Maamar has nothing to disclose.Conflict of interest: Dr. Thibault has nothing to disclose.Conflict of interest: Dr. Le Tulzo has nothing to disclose.Conflict of interest: Dr. TADIE has nothing to disclose. ER -