TY - JOUR T1 - Treatable traits qualifying for non-pharmacological interventions in COPD patients upon first referral to a pulmonologist: the COPD <em>sTRAITosphere</em> JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00438-2020 SP - 00438-2020 AU - Alex J. van ’t Hul AU - Eleonore H. Koolen AU - Jeanine C. Antons AU - Marianne de Man AU - Remco S. Djamin AU - Johannes C.C.M. in ’t Veen AU - Sami O. Simons AU - Michel van den Heuvel AU - Bram van den Borst AU - Martijn A. Spruit Y1 - 2020/01/01 UR - http://openres.ersjournals.com/content/early/2020/09/01/23120541.00438-2020.abstract N2 - Introduction The present study assessed the prevalence of nine treatable traits (TTs) pinpointing non-pharmacological interventions in patients with COPD upon first referral to a pulmonologist, how these TTs co-occurred, and whether and to what extent the TTs increased the odds having a severely impaired health status.Methods Data were collected from a sample of 402 COPD patients. A second sample of 381 patients with COPD was used for validation. Nine TTs were assessed: current smoking status, activity-related dyspnea, frequent exacerbations &lt;12 months, severe fatigue, depressed mood, poor physical capacity, low physical activity, poor nutritional status, and a low level of self-management activation. For each TT the odds ratio of having a severe health status impairment was calculated. Furthermore, a graphic representation was created, the COPD sTRAITosphere, to visualise TTs prevalence and odds ratio.Results On average 3.9±2.0 TTs per patient were observed. These TTs occurred relatively independently of each other and coexisted in 151 unique combinations. A significant positive correlation was found between the number of TTs and CCQ total score (r=0.58; p&lt;0.001). Patients with severe fatigue (odds ratio, OR: 8.8), severe activity-related dyspnea (OR: 5.8) or depressed mood (OR: 4.2) had the highest likelihood of having a severely impaired health status. The validation sample corroborated these findings.Conclusions Upon first referral to a pulmonologist, COPD patients show multiple TTs indicating them to several non-pharmacological interventions. These TTs coexist in many different combinations, are relatively independent and increase the likelihood of having a severely impaired health status.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. van ‘t Hul has nothing to disclose.Conflict of interest: Dr. Koolen has nothing to disclose.Conflict of interest: Dr. Antons has nothing to disclose.Conflict of interest: Dr. de Man has nothing to disclose.Conflict of interest: Dr. Djamin has nothing to disclose.Conflict of interest: Dr. in ‘t Veen reports grants from Boehringer Ingelheim, grants from Teva, grants from Chiesi, personal fees from Sanofi, outside the submitted work.Conflict of interest: Dr. Simons has nothing to disclose.Conflict of interest: Dr. van den Heuvel has nothing to disclose.Conflict of interest: Dr. van den Borst has nothing to disclose.Conflict of interest: Dr. Spruit reports grants from Netherlands Lung Foundation, grants from Stichting Astma Bestrijding, grants and personal fees from Astra Zeneca, grants and personal fees from Boehringer Ingelheim, outside the submitted work. ER -