RT Journal Article SR Electronic T1 Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia JF ERJ Open Research JO erjor FD European Respiratory Society SP 00210-2019 DO 10.1183/23120541.00210-2019 VO 6 IS 3 A1 Valentina Ferraro A1 Eleni-Rosalina Andrinopoulou A1 Anna Marthe Margaretha Sijbring A1 Eric G. Haarman A1 Harm A.W.M. Tiddens A1 Marielle W.H. Pijnenburg YR 2020 UL http://openres.ersjournals.com/content/6/3/00210-2019.abstract AB Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in children with PCD. The objectives of the present study were to quantify airway and artery dimensions on chest CT in a cohort of children with PCD and compare these with control children to analyse the influence of covariates on airway and artery dimensions.Chest CTs of 13 children with PCD (14 CT scans) and 12 control children were collected retrospectively. The bronchial tree was segmented semi-automatically and reconstructed in a three-dimensional view. All visible airway–artery (AA) pairs were measured perpendicular to the airway centre line, annotating per branch inner and outer airway and adjacent artery diameter and computing inner airway diameter/artery ratio (AinA ratio), outer airway diameter/artery ratio (AoutA ratio), wall thickness (WT), WT/outer airway diameter ratio (Awt ratio) and WT/artery ratio.In the children with PCD (38.5% male, mean age 13.5 years, range 9.8–15.3) 1526 AA pairs were measured versus 1516 in controls (58.3% male, mean age 13.5 years, range 8–14.8). AinA ratio and AoutA ratio were significantly higher in children with PCD than in control children (both p<0.001). Awt ratio was significantly higher in control children than in children with PCD (p<0.001).Our study showed that in children with PCD airways are more dilated than in controls and do not show airway wall thickening.Chest CT is the gold standard for detecting structural abnormalities in patients with PCD, and this study is the first on quantitative assessment of airway and artery abnormalities in children with PCD https://bit.ly/2XZYWjU