TY - JOUR T1 - Predictors of massive haemoptysis after a first episode of mild-to-moderate haemoptysis in patients with cystic fibrosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00382-2020 VL - 6 IS - 3 SP - 00382-2020 AU - Geoffrey Pavaut AU - Maeva Kyheng AU - Olivier Le Rouzic AU - Thierry Perez AU - Benoit Wallaert AU - Anne Prevotat Y1 - 2020/07/01 UR - http://openres.ersjournals.com/content/6/3/00382-2020.abstract N2 - The main cause of death of cystic fibrosis (CF) patients is respiratory disease due to secondary infections, haemoptysis, pneumothorax, and respiratory failure [1]. In a study of 129 French CF patients who died between 2007 and 2010 without receiving lung transplantation, 8.5% of deaths were due to haemoptysis [2]. Factors associated with an increased risk of haemoptysis in CF patients include older age, advanced lung disease (forced expiratory volume in 1 s (FEV1) <70% predicted), airway colonisation by Pseudomonas aeruginosa [3], CF-related diabetes, portal hypertension, and liver cirrhosis [4]. To our knowledge, there have been no studies of the risk factors for the development of massive haemoptysis (MH) in CF patients who have previously experienced an episode of mild-to-moderate haemoptysis.Mild-to-moderate haemoptysis (m-mH) is common in patients with cystic fibrosis but the risk of subsequent massive haemoptysis (MH) is not known. Allergic bronchopulmonary aspergillosis and diabetes were significant predictors of MH subsequent to m-mH. https://bit.ly/30093HwThe authors wish to thank Julien Labreuche (Univ. Lille, CHU Lille, ULR 2694 - METRICS: évaluation des technologies de santé et des pratiques médicales, F-59000 Lille, France) for help with the statistical analysis and Anne M. O'Rourke for editing a version of the manuscript. ER -